TYPE 1 DIABETES MELLITUS

This study compares a new insulin pump system (Omnipod 6) with the current version (Omnipod 5) in 200 people aged 14-75 with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a h…

This study tests whether tirzepatide, a drug used for type 2 diabetes and weight loss, can help people with type 1 diabetes. 44 adults with type 1 diabetes and a BMI of 27 or higher will receive either tirzepatide or a placebo for 6 weeks. Researchers will measure how the drug af…

This study tests a flexible digital insulin dose calculator for children under 12 with type 1 diabetes who use multiple daily injections. About 440 kids will either get standard care or standard care plus the calculator for 6 months. The goal is to see if the tool helps improve b…

This study tests whether a low-dose glucagon injection before moderate exercise can prevent blood sugar drops in 18 adults with type 1 diabetes who use an automated insulin pump. Participants will exercise after a meal, and researchers will compare blood sugar changes when using …

This study compares two treatments to delay type 1 diabetes in people who are at high risk but don't have symptoms yet. One group gets 2 infusions of ATG, the other gets 14 infusions of teplizumab. Researchers want to see if the shorter ATG treatment works as well or better at pr…

This study tests whether using a lower ketone alarm (1.0 vs 1.5 mmol/L) can safely reduce the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes taking dapagliflozin, a drug usually used for type 2 diabetes. About 115 adults will wear a continuous ketone monitor a…

This study tests a web-based education program for teenagers with type 1 diabetes and their mothers. The program aims to improve eating habits, blood sugar control, and self-management. Researchers will compare teens who use the website alone, teens and mothers together, and thos…

This study tests whether a weekly medication called tirzepatide can help adults with type 1 diabetes use their insulin pump without counting carbohydrates at meals. About 105 participants in Canada and Switzerland will be randomly assigned to receive tirzepatide or continue stand…

This study looks at whether special education and motivational interviews for parents can help children aged 8-12 with type 1 diabetes manage their condition better and improve their quality of life. About 42 families will take part. The goal is to see if supporting parents leads…

This study tests a new way to treat diabetic foot ulcers, which are slow-healing wounds common in people with diabetes. Researchers will use ultrasound to help deliver propolis, a natural bee product with anti-inflammatory properties, into the skin. About 80 adults with diabetes …

This study will test whether artificial intelligence (AI) can effectively screen for diabetic retinopathy (eye damage) in 400 children with type 1 diabetes. Participants will have their eyes photographed and the AI's results will be compared to standard exams. The goal is to see …

This study looks at whether resistance training (like lifting weights) can reduce depression and improve sleep and quality of life in women with type 1 diabetes. Researchers will enroll 78 women who have had diabetes for over 5 years and have mild to moderate depression. Particip…

This study looks back at medical records of 500 Chinese adults with type 1 diabetes to see if adding glucose-lowering pills to their insulin helps control blood sugar better than insulin alone. The main goal is to compare average blood sugar levels (HbA1c) between the two groups …

This study looks at whether fear of hypoglycemia (low blood sugar) changes how the heart works, how active kids are, and how well they can exercise. About 67 children and teens aged 10-18 with type 1 diabetes will answer surveys and have their heart rate, blood pressure, and oxyg…

This study looks at why women with type 1 diabetes are more likely to develop polycystic ovary syndrome (PCOS) and high male hormone levels. Researchers will compare 60 people across five groups, including women with and without diabetes and PCOS, as well as men with diabetes. Th…

This study looks at how different temperatures (cold, normal, and hot) affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in three different temperature rooms while researchers monitor their blood sugar, heart rate, and b…

This study looks at how to safely use a diabetes medication (SGLT2 inhibitor) in people with type 1 diabetes and mild-to-moderate chronic kidney disease. Researchers will track blood sugar and ketone levels using continuous monitors to identify risk factors for diabetic ketoacido…

This study looks at whether the arthritis drug sulfasalazine makes the common diabetes blood test (HbA1c) unreliable. The drug can lower HbA1c levels, potentially hiding new diabetes cases or making existing diabetes seem better controlled than it is. Researchers will use continu…

This study looks at how high-fat vs. low-fat meals and menstrual cycle phases affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized meals and have their blood sugar tracked. The goal is to help create better insulin …

This study involves 100 university students with type 1 diabetes. Researchers will test their carb counting knowledge and give a short education session, then check blood sugar control (HbA1c) after three months. The goal is to see if better carb counting leads to improved diabet…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young adults with type 1 diabetes. Twenty people aged 15-24 will drink a sports drink and have their blood vessel function measured. The goal is to understand if the…