TYPE 1 DIABETES MELLITUS

This study tests whether a daily pill called fenofibrate can slow or prevent worsening eye disease (diabetic retinopathy) in adults with type 1 diabetes. About 412 participants with early eye damage are taking either the drug or a placebo for several years. The goal is to see if …

This study tests whether a smartphone app called Diabetes M helps people with type 1 diabetes calculate their insulin doses more accurately than their usual method. Thirty adults will use the app for two weeks and compare their blood sugar control to two weeks without it. The goa…

This study tests a treatment called Diamyd in people aged 12 to 29 who were recently diagnosed with type 1 diabetes and have a specific genetic marker. The goal is to see if it can help preserve the body's ability to produce insulin, which may lead to better blood sugar control. …

This study tests a new drug called brivekimig in people recently diagnosed with type 1 diabetes. The goal is to see if it can help preserve the body's ability to make some insulin, reducing the need for injected insulin. About 84 adults and adolescents will receive either the dru…

This study tests a hybrid closed-loop insulin pump system (mylife CamAPS FX) in 30 adults with type 1 diabetes who have chronically high blood sugar and psychological challenges. Participants either start the pump immediately or after a 3-month delay. The goal is to see if the sy…

This study tests whether a daily probiotic supplement can reduce inflammation in children and teens newly diagnosed with type 1 diabetes. Researchers believe that changes in gut bacteria may worsen the disease. Participants take either the probiotic or a placebo for several month…

This phase 3 trial tests whether transplanting insulin-producing cells (islets) from donors can help adults with type 1 diabetes who still have dangerous low blood sugar episodes despite intensive insulin therapy. The goal is to improve blood sugar control and eliminate severe hy…

This early-phase study tests a new vaccine made from a person's own immune cells and a small piece of insulin protein. The goal is to see if it is safe and possible to teach the immune system to stop destroying the pancreas cells that make insulin. Six adults with type 1 diabetes…

This study tests whether giving two immune-calming drugs, rituximab followed by abatacept, can help people newly diagnosed with type 1 diabetes keep making their own insulin longer than rituximab alone. About 74 participants aged 8 to 45 will receive the combo or a placebo over 4…

This study tests a device called the Cell Pouch, which is implanted in the abdomen to house insulin-producing cells for people with Type 1 Diabetes who have dangerous low blood sugar episodes. The goal is to see if the device is safe and can help the cells survive long-term, pote…

This study tests if transplanting insulin-making cells from donors can help people with type 1 diabetes control blood sugar better and possibly stop insulin shots. Participants get anti-rejection drugs to protect the new cells. Up to 10 people will be followed for 5 years to see …

This study looks at whether Swedish massage or yoga can help lower blood sugar levels in children aged 6 to 12 with type 1 diabetes. Both techniques are relaxing and may reduce stress, which can help control blood sugar. The study involves 50 children from Cairo who do not have o…

This study tests whether a probiotic called Lactiplantibacillus plantarum 299v can reduce inflammation and help preserve the body's ability to produce insulin in people recently diagnosed with type 1 diabetes. About 60 participants aged 3 to 45 will take the probiotic or a placeb…

This study follows over 1,400 people with type 1 diabetes who were part of an earlier trial comparing intensive versus standard blood sugar control. Researchers are tracking long-term health issues like eye, kidney, nerve, and heart problems, as well as physical and mental declin…

This study looks at whether being overweight or having diabetes changes certain chemical marks on sperm DNA. Researchers will check if a 3-month lifestyle or blood sugar program can improve these marks. The study involves 40 men aged 18-65 who are overweight, with or without diab…