Can a common diabetes pill make insulin therapy safer and more effective for type 1 diabetes?
NCT ID NCT03878459
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This phase 4 trial tests whether adding pioglitazone to an SGLT2 inhibitor (dapagliflozin) and insulin can lower blood sugar more effectively in people with type 1 diabetes while preventing a rise in ketones, which can lead to a dangerous condition called ketoacidosis. About 120 adults with type 1 diabetes and poor blood sugar control will receive dapagliflozin for 12 weeks, then be randomly assigned to pioglitazone or a placebo for another 16 weeks. Researchers will track changes in HbA1c, ketone levels, and insulin needs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pioglitazone
- What this could lead to
- If it works, this combination could offer a new way to improve blood sugar control in type 1 diabetes while reducing the risk of a dangerous side effect called ketoacidosis.
- What could go wrong
- This is a mid-stage trial with 120 participants, so results may not apply to everyone. Pioglitazone can cause side effects like weight gain and fluid retention.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TYPE 1 DIABETES MELLITUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dasman Diabetes Institute
Kuwait City, Kuwait
-
Endocrinology and Diabetes Center, Rambam Medical Center
Haifa, Israel
-
University Health System Texas Diabetic Institute
San Antonio, Texas, 78207, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a smart pen take the guesswork out of insulin dosing?
- AI takes the wheel: could a smart algorithm optimize insulin pumps from home?
- Real-World test of automated insulin system aims to improve blood sugar control for type 1 diabetes
- Can a wearable sensor help young people with type 1 diabetes tame blood sugar swings?
- Can a smartphone app help teens tame type 1 diabetes?
- Smartphone nursing visits could transform diabetes care for teenagers