Could a custom vaccine retrain the immune system in type 1 diabetes?
NCT ID NCT04590872
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new type of immunotherapy for type 1 diabetes. The treatment uses a vaccine made from the patient's own immune cells and a piece of insulin-producing cell protein. The goal is to teach the immune system to stop attacking the pancreas, potentially preserving some insulin production. Six adults with type 1 diabetes who use insulin and have no other diabetes complications are participating.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
A vaccine made from the patient's own immune cells (dendritic cells) combined with a piece of insulin-producing cell protein (proinsulin peptide C19-A3)
What this could lead to
If it works, this could point toward a way to preserve the body's ability to make some insulin, potentially reducing the need for injected insulin and preventing long-term complications.
What could go wrong
This is a very early, small pilot study with only 6 people, so results may not apply broadly. The vaccine may not work, and there could be side effects like allergic reactions or immune system issues.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TYPE 1 DIABETES MELLITUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
City of Hope Medical Center
Duarte, California, 91010, United States