Can a simple alarm prevent a deadly complication in type 1 diabetes?
NCT ID NCT07225465
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a continuous ketone monitor with a lower alarm threshold (1.0 vs 1.5 mmol/L) can reduce the risk of diabetic ketoacidosis in people with type 1 diabetes who take dapagliflozin, a drug typically used for type 2 diabetes. 115 adults will wear a dual glucose/ketone monitor and take dapagliflozin for 12 weeks. The goal is to find the safest way to use this drug in type 1 diabetes by catching rising ketones early.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dapagliflozin (Forxiga)
- What this could lead to
- If successful, this study could help establish safe guidelines for using SGLT2 inhibitors in type 1 diabetes, potentially improving blood sugar control and reducing complications.
- What could go wrong
- This is a small, early-phase trial (115 participants) and does not yet prove safety or effectiveness. The risk of diabetic ketoacidosis remains a serious concern, and the optimal ketone threshold is still uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Austin Health
Heidelberg, Victoria, 3084, Australia
-
Baker Heart and Diabetes Institute
Melbourne, Victoria, 3004, Australia
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St Vincent's Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
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The Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
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