Could a tiny glucagon shot before workout stop blood sugar crashes in type 1 diabetes?

NCT ID NCT07427251

Recruiting now Disease control Sponsor: Steno Diabetes Center Copenhagen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to see if glucagon keeps blood sugar more stable during and after activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose glucagon
What this could lead to: If it works, this could offer a new way to prevent exercise-induced low blood sugar in people with type 1 diabetes, reducing reliance on extra carbs.
What could go wrong: This is a small, early-phase trial with only 18 participants, so results may not apply widely. Glucagon can cause nausea or allergic reactions in some people.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus exercise-induced hyperinsulinism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES MELLITUS

Contacts and locations

Locations

Steno Diabetes Center Copenhagen
RECRUITING

Herlev, Denmark

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