Could a new injection help people with New-Onset type 1 diabetes keep making insulin?

NCT ID NCT07142252

Recruiting now Disease control Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the drug or a placebo every two weeks for 26 weeks, and their insulin production will be measured after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rezpegaldesleukin (NKTR-358)
What this could lead to: If it works, this could help people with new-onset type 1 diabetes keep making some of their own insulin, reducing the need for injected insulin.
What could go wrong: This is an early Phase 2 trial with only 66 people, so results may not apply to everyone. The drug may not preserve insulin production better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 1 DIABETES MELLITUS

Contacts and locations

Locations

Barbara Davis Center for Diabetes
RECRUITING

Aurora, Colorado, 80045, United States
Benaroya Research Institute
RECRUITING

Seattle, Washington, 98101, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Joslin Diabetes Center
RECRUITING

Boston, Massachusetts, 02115, United States
University of British Columbia
NOT_YET_RECRUITING

Vancouver, British Columbia, V5Z4H4, Canada
University of Florida
RECRUITING

Gainesville, Florida, 32610, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84113, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States

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