Endocrine pancreas disorder

This study tests a new medicine called HM15275 in people with type 2 diabetes. The goal is to see if it can lower blood sugar levels (HbA1c) safely over 36 weeks. About 180 adults who manage their diabetes with diet, exercise, or metformin will take part. Half will get the drug, …

This study looks at whether the diabetes drug pioglitazone can improve how the liver processes energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver mitochondrial function using special tracers before and after 16 weeks…

This trial tests whether a silicone-based or a hydrocolloid patch placed under insulin pumps or glucose monitors can prevent contact dermatitis from coming back in children aged 2-18. Participants will use different patches and attend visits for skin exams, ultrasounds, and quest…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests a new medicine called ersodetug for people whose tumors cause dangerously low blood sugar that standard treatments can't control. About 16 adults with insulin-producing tumors will receive the drug alongside their usual care. The main goal is to see if ersodetug …

This trial tests whether using a diabetes-specific questionnaire during annual check-ups can improve the quality of care for people with type 2 diabetes. About 2,000 adults with type 2 diabetes from 30 general practices in Denmark will take part. Half of the practices will use th…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This trial is testing an experimental once-daily pill called ASC30 in adults who are overweight or have obesity and also have type 2 diabetes. The study aims to see if ASC30 can help with long-term weight loss and improve blood sugar control compared to a placebo. Participants wi…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study tests whether an AI app called SnapD, which recognizes Thai food and estimates nutrition, can help people with type 2 diabetes and overweight improve their blood sugar control. Some participants will also use a continuous glucose monitor (CGM) that tracks sugar levels …

This pilot study tests whether intermittent use of a continuous glucose monitor (CGM), along with regular medical visits, diabetes education, and psychological support, can improve blood sugar control in children and adolescents with high-risk type 1 diabetes in the Dominican Rep…

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This phase 2 trial tests whether dulaglutide, a drug used for type 2 diabetes, can improve small blood vessel function in adults with type 1 diabetes. The study involves 47 participants aged 18-40 with long-standing type 1 diabetes. Researchers measure blood flow and insulin sens…

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This trial tests whether 16 weeks of exercise training, liraglutide treatment, or both can improve blood vessel function and insulin sensitivity in adults with type 2 diabetes. Participants are randomly assigned to one of three groups and are studied before and after the interven…

This study tests whether an automated insulin delivery system (CamAPS FX) can help women with type 1 diabetes maintain better blood sugar control before and during pregnancy, compared to their usual insulin routine. The trial will enroll 305 women aged 18-45 who are either planni…

This study is testing a new wearable device that continuously measures both glucose (sugar) and ketone levels in adults with type 1 diabetes. The device is worn for 15 days and its readings are compared to standard lab tests. The goal is to see if it is accurate and safe enough f…

This trial tests whether a mobile app called NutriSteppe can improve blood sugar control and weight loss in adults with type 2 diabetes or obesity who are already taking GLP-1 medications like semaglutide. Over 12 weeks, half the participants will use the app for personalized mea…

This study tests if a new insulin that is injected just once a week works as well as daily insulin shots to control blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly insulin or a standard daily insulin for …

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This study tests whether a nutrition program that provides twice-daily meal delivery for up to 90 days after hospital discharge, plus diet education, can reduce food insecurity in people with type 1 or type 2 diabetes. About 160 hospitalized patients who screen positive for food …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This study tests a new medicine called UBT251, given as a weekly shot, in 300 adults with type 2 diabetes. Some participants will get UBT251, others will get a placebo or an existing drug (semaglutide). The goal is to see if UBT251 can safely lower blood sugar and help with weigh…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This trial tests whether a smartphone app called SPARK can help women with gestational diabetes manage their condition. Participants receive standard care, and some also use the app to support healthy eating, physical activity, and blood sugar tracking. The study looks at blood s…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This early-stage study is testing a new treatment called GNTI-122 for adults who were recently diagnosed with type 1 diabetes. The therapy is made from a person's own blood cells and is designed to help rebalance the immune system. Sixteen participants will receive either a low o…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests two higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide in teenagers aged 10 to 17 with type 2 diabetes. The goal is to see if these doses are safe and help control blood sugar and weight. Participants will receive weekly injections for about 8 mont…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This Phase 2 trial tests whether a new drug called icovamenib can help people with type 2 diabetes who still have high blood sugar despite taking other medications. About 60 adults aged 18 to 70 will receive either icovamenib or a placebo daily for 12 weeks. The main goal is to s…

This trial tests three different ways to reconnect the digestive tract after stomach cancer surgery to see which one best controls blood sugar in people who also have type 2 diabetes. Participants will be randomly assigned to one of three surgical procedures. The main goal is to …

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study compares a new drug, zanzalintinib, to the current standard drug everolimus in people with advanced neuroendocrine tumors that have already been treated. The goal is to see which drug better slows tumor growth. About 440 participants will be randomly assigned to one of…

This study tests whether a 12-week sleep-focused behavioral program can help adults with type 1 diabetes improve their sleep and blood sugar control. Participants learn sleep hygiene, stress management, and routines to target 7-9 hours of quality sleep. The study tracks sleep wit…

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This study is testing a new implantable insulin pump (MIIPS 2020) in 40 adults with type 1 diabetes whose blood sugar is hard to control with standard insulin shots or external pumps. The pump is placed inside the body and delivers insulin directly, aiming to reduce dangerous hig…

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 mont…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This trial tests whether a low-calorie diet combined with intensive lifestyle coaching can help adults with type 2 diabetes achieve remission—meaning blood sugar levels return to normal without medication. Participants are randomly assigned to either the intervention or standard …

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see i…

This study tests whether a behavioral program that reduces evening light exposure and encourages finishing meals at least four hours before bedtime can improve how the body handles sugar. Overweight adults aged 18-45 who habitually sleep less than 6.5 hours per night will be rand…

This study tests whether helping people with diabetes find local resources (like food or housing help) and pairing them with a peer supporter can improve blood sugar and blood pressure. About 694 adults with diabetes who have trouble controlling their condition will be randomly a…

This trial tests whether extending nightly sleep by about 2 hours in adults who habitually sleep less than 6.5 hours can improve insulin sensitivity and reduce cardiometabolic risk. Participants are overweight or obese adults aged 18-45 without diabetes or sleep disorders. They a…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This trial tests whether an educational program using continuous glucose monitors (CGMs) can help older adults with type 2 diabetes use insulin more safely. Participants aged 75 and older who are at high risk for low blood sugar will either attend group education sessions with CG…

This study tests whether giving a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to under 21 who were recently diagnosed with type 1 diabetes. The main goal is to see if th…

This trial is testing whether semaglutide, a medication used for obesity, can improve heart health in young adults (ages 18-30) who have both type 1 diabetes and obesity. Participants will receive either semaglutide or a placebo for a year. The study will measure changes in body …

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This trial is testing whether an experimental drug called BGM0504 can help people with early-stage type 2 diabetes and obesity achieve better blood sugar control and weight loss than a standard treatment, semaglutide. Participants will receive either BGM0504 or semaglutide as a o…

This phase 3 study tests whether taking two diabetes medications together—elecoglipron and dapagliflozin—works better than either drug alone for controlling blood sugar in adults with type 2 diabetes. The trial enrolls about 2,000 people whose diabetes is not well managed by life…

This phase 3 study tests whether a new oral drug called elecoglipron can help adults with type 2 diabetes better manage their blood sugar when added to their current insulin and other diabetes medications. About 600 participants will receive either elecoglipron or a placebo daily…

This study tests whether meals designed for South Asian and Filipino cultures, following diabetes guidelines, can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for a month while eating their usual diet and t…

This study tests a treatment called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function better than standard care. Participants will be randomly assigned to receive…

This study tests an experimental drug called elecoglipron, taken alone or together with the existing medication dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled. About 800 participants will receive either the new drug, a placebo, or a combina…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests a new daily pill called elecoglipron in adults with type 2 diabetes and reduced kidney function. Participants also take dapagliflozin, a standard diabetes medicine. The goal is to see if elecoglipron improves blood sugar control, body weight, and blood pressure c…

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study tests a new automatic insulin pump (Omnipod M) in 350 adults with type 2 diabetes who already use insulin. The pump adjusts insulin delivery on its own to keep blood sugar in a healthy range. The goal is to see if it improves blood sugar control and is safe to use.

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study compares continuous glucose monitors (CGMs) to standard fingerstick testing in 180 pregnant women with type 2 diabetes. The goal is to see if CGMs reduce the number of large babies and improve blood sugar control. Participants will use either a CGM or traditional finge…

This early-stage study tests a new drug, AMG 127, to see if it is safe for people. It involves 162 healthy adults and people with type 2 diabetes. Researchers will give single or multiple doses and watch for side effects. This is a first step to see if the drug can be developed f…

This phase 2 study tests belzutifan, a daily pill that blocks a protein called HIF-2α, in people with advanced rare cancers like pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain other solid tumors. The goal is to see if …

This study will test whether adding a probiotic supplement to standard diabetes medications (metformin or insulin) improves blood sugar control and reduces inflammation in pregnant women with gestational diabetes. Two hundred women diagnosed between 18-26 weeks of pregnancy will …

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This trial tests whether an artificial intelligence system can help optimize insulin pump settings remotely for people with type 1 diabetes. The AI analyzes continuous glucose monitor and pump data to suggest personalized adjustments, which a doctor then reviews before sending to…

This study investigates whether combining bariatric surgery with a GLP-1 receptor agonist (semaglutide) leads to greater and more sustained weight loss than surgery alone in people with obesity. Researchers will follow 400 participants across multiple centers in China for up to t…

This trial investigates an experimental drug called GUB-UCN2 for people with obesity and type 2 diabetes. The study includes healthy volunteers and those with the conditions, testing the drug alone or alongside standard care. The main goal is to check safety and how the drug beha…

Black individuals often have lower levels of natriuretic peptides, heart hormones that help regulate metabolism. This trial tests whether raising those hormone levels with a drug called sacubitril/valsartan can improve insulin sensitivity and energy expenditure. About 200 Black a…

This study tests whether a special nutritional supplement, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar over 24 weeks. One hundred participants will receive either the active supplement or a placebo, alongside their usual di…

This trial tests whether denosumab, a drug already used for bone conditions, can protect the beta cells that produce insulin in people with early type 1 diabetes. Researchers believe the same biological pathway that denosumab targets in bones may also help preserve beta cell func…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This study tests a 10-week virtual program called Acceptance Based Coping (ABaCo) for Hispanic/Latinx military patients with type 2 diabetes. The program, delivered by a bilingual health coach, teaches skills to cope with diabetes-related stress and improve self-care. Researchers…

This trial tests whether GlycoQuest, a video game that connects to a continuous glucose monitor and adapts using artificial intelligence, can help children aged 6 to 17 who were diagnosed with type 1 diabetes in the past three months. The game includes a glucose-responsive avatar…

This phase 2 trial tests whether adding an experimental drug called AT673 to the standard diabetes medication semaglutide leads to greater weight loss and better blood sugar control in adults with type 2 diabetes who are overweight or obese. Participants receive either a low or h…

This Phase 2 trial tests whether HRS9531 tablets can improve blood sugar control in people with type 2 diabetes who haven't achieved good control with lifestyle changes or metformin alone. About 240 participants will receive either the drug or a placebo for 20 weeks. The main goa…

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This trial tests whether adding an antibiotic-impregnated bone graft substitute (Cerament G) to standard surgery improves healing of heel bone infections (calcaneal osteomyelitis) in people with diabetes. Thirty participants will be randomly assigned to receive either partial rem…

This study tests whether a structured exercise and nutrition program can slow the loss of muscle mass, strength, and function in adults aged 65 and older with type 2 diabetes and obesity who are taking semaglutide. Participants receive either standard health advice or a 26-week p…

This study investigates whether adding melatonin to standard diabetes care can improve symptoms of diabetic peripheral neuropathy, a common complication causing pain and numbness in the feet and hands. The trial includes 60 adults aged 40-75 with type 2 diabetes and diagnosed ner…

This study looks at whether replacing some wheat flour with chickpea flour in bread can lower blood sugar rises after eating. Healthy adults and people with type 2 diabetes will eat bread made with finely or coarsely ground chickpea flour, and their blood sugar will be tracked co…

This study tests whether dimethyl fumarate, a drug already used for multiple sclerosis, can help preserve the body's ability to make insulin in adults with type 1 diabetes. About 96 people will either receive the drug plus standard insulin therapy or insulin alone for 24 weeks, t…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This study compares two exercise programs—high-intensity interval training (short bursts of fast stair climbing) and continuous endurance training (steady walking)—in adults with prediabetes. The goal is to see which approach better improves blood sugar control, body mass index, …

This study tests whether a structured nutrition counselling program can improve diet, blood sugar, blood pressure, and quality of life in adults who have both type 2 diabetes and hypertension. About 308 participants from 14 hospitals in Ethiopia will either receive six individual…

This study tests a web-based program called Web-SUCCEED that helps veterans with chronic illness and their informal caregivers work together to manage the condition. The program includes three weekly online modules and brief phone calls with staff, focusing on stress coping and c…

This study tests a smartphone program called Smart Walk, designed specifically for African American women who are not very active. The program includes an app, virtual coaching, and text messages to encourage more physical activity. Researchers want to see if it helps women exerc…

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This study investigates whether canagliflozin, a diabetes medication, can improve cognitive function in people with type 2 diabetes who also have mild cognitive impairment. The trial uses brain scans to measure changes in blood flow after insulin inhalation, along with standard c…

This early-stage trial tests a microneedle patch called DWRX5003 that delivers semaglutide, a drug used for obesity and type 2 diabetes. The study involves 72 healthy adults to check safety and how well the drug enters the body compared to standard injections. It is not yet testi…

This study tests whether personalized nutrition counseling, guided by continuous glucose monitor (CGM) data, helps people with type 2 diabetes better control their blood sugar. Participants are randomly assigned to receive either CGM-based nutrition advice, standard nutrition edu…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This trial compares two ways of monitoring blood sugar in adults recently diagnosed with type 2 diabetes (within the last 3 months). Half of the 80 participants use a real-time continuous glucose monitor (CGM) that provides constant feedback, while the other half use standard fin…

This phase 3 study tests a new oral drug, elecoglipron, against the approved pill semaglutide in adults with type 2 diabetes who also have increased heart risk. The goal is to see which works better for lowering blood sugar and body weight over about a year. Participants take one…

This trial investigates whether time-restricted eating (TRE) — eating all food within an 8-10 hour window each day — can improve kidney function in people with type 2 diabetes who have elevated protein in their urine (microalbuminuria). All 25 participants follow the same TRE sch…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This trial tests whether inclisiran, an injectable medication, can lower LDL cholesterol in patients who have multiple health conditions and take many drugs that interfere with standard statin therapy. Participants must be taking five or more prescription medications and have con…

This study tests a structured behavioral program called the BMW Toolkit for pregnant women with both gestational diabetes and pregnancy-induced hypertension. The toolkit includes diet, exercise, sleep, and self-care guidance delivered over 7-8 sessions. Researchers will compare b…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study compares two types of walking exercise for people with type 2 diabetes: walking on a downhill slope versus walking on flat ground. Over 8 weeks, participants will walk twice a week on a treadmill under supervision. Researchers will measure changes in walking distance, …

This study explores whether a short-term low-energy diet (using meal replacements) can help adolescents aged 12–17 with obesity and type 2 diabetes lose weight and potentially achieve diabetes remission. Participants follow the diet for 12 weeks, then gradually reintroduce food o…

This trial investigates whether exosomes—tiny particles from human umbilical cord stem cells—can safely improve blood sugar control in adults with type 2 diabetes. Participants receive weekly intravenous infusions of the exosome product or a control for eight weeks. The study mea…

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This study tests whether a simple breathing exercise, called Inspiratory Muscle Strength Training (IMST), can safely lower blood pressure in pregnant women during their third trimester. Participants do 5 to 8 minutes of breathing against light or moderate resistance each day for …

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This pilot study investigates whether taking myo-inositol (a vitamin-like substance) along with folic acid can improve blood sugar control and reduce oxidative stress in women diagnosed with gestational diabetes. About 40 pregnant women will be randomly assigned to receive either…

This study tests whether a real-time continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes keep their blood sugar in a healthy range better than standard finger-prick testing. About 240 women in early pregnancy will either wear the CGM device for most of thei…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study will follow 2,200 children and adults with type 1 diabetes who are using the Omnipod 5 system, a tubeless insulin pump that automatically adjusts insulin based on continuous glucose monitor readings. Over 12 months, researchers will track how often severe low or high b…

This Phase 3 trial will test a new once-daily insulin, GZR33, against the standard insulin degludec (Tresiba) in 350 adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The main goal is to see how well GZR33 lowers blood sugar over 26 weeks c…

This trial tests whether a pulse electric field ablation system can help adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The study enrolls 20 people aged 18 to 70 with a specific range of blood sugar levels. Researchers will measure chang…

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This study tests whether a 12-week personalized exercise program done at home and guided by a mobile app and wearable device can improve blood sugar control and physical fitness in adults with type 2 diabetes. Participants are 40 to 69 years old, newly diagnosed or with diabetes …

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a fully closed-loop insulin system (which automatically adjusts insulin delivery) works better than a standard insulin pump for people with type 2 diabetes. Eighty adults who have used an insulin pump for at least six months will try both methods for 12 w…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This study tests whether wearing a continuous glucose monitor (CGM) helps pregnant women with gestational diabetes control their blood sugar and improve outcomes for both mother and baby. Researchers will also examine how socioeconomic status, diet, and culture affect results. Th…

This study compares two different strength training schedules—non-linear and linear periodization—in people with type 2 diabetes. Over 8 weeks, 48 participants will do supervised workouts three times a week or receive usual care. Researchers will measure changes in exercise capac…

This early-stage trial is testing a new experimental medicine called NNC1679-0001 for type 2 diabetes. Researchers want to see if it is safe and how well the body tolerates it. The study includes both healthy volunteers and people with type 2 diabetes, who will receive either a s…

This study compares two digital approaches—live video classes and simple text messages—against traditional in-person classes to help 150 Hispanic/Latino adults with type 2 diabetes better manage their condition. The goal is to see if these digital tools can improve blood sugar co…

This study tests whether a special anti-inflammatory diet can lower inflammation and improve blood sugar control in people with type 2 diabetes. 88 adults will be randomly assigned to either the anti-inflammatory diet or standard diabetes dietary advice for 4 weeks. Researchers w…

This study tests whether peer coaching can help older adults (55+) with uncontrolled type 2 diabetes in rural Kentucky better manage their condition. Participants are paired with trained peer coaches who call them weekly or bi-weekly to discuss self-care and goals. The study will…

This study tests if leg exercise (like pedaling) is better than arm exercise for controlling blood sugar, weight, and stress in pregnant women with gestational diabetes. 108 women in their second trimester will exercise three times a week for eight weeks. The goal is to find a sa…

This study tests whether regular phone calls from a trained peer coach can help older adults (55+) with type 2 diabetes in rural Kentucky improve their self-care. Participants are divided into groups that receive weekly or bi-weekly coaching calls to discuss goal-setting and diab…

This study looks at whether THC, the active part of marijuana, can change how the body handles sugar and affects blood vessel health in people with type 2 diabetes. About 30 adults will take THC or a placebo for two weeks, then have their blood sugar and blood vessel function tes…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This early-phase study tests whether dichloroacetate (DCA), a drug used safely for decades in a rare metabolic disorder, can improve brain function during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen participants with a history of severe hypoglycemia or …

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This early-stage study is testing a new insulin pill (SCD0503) in 16 men with type 1 diabetes. The goal is to see how well the pill works compared to standard injected insulin and whether it is safe. Participants will have their blood sugar carefully controlled during the study t…

This study tests whether a continuous glucose monitor (CGM) can improve pregnancy outcomes for women with gestational diabetes compared to standard finger-prick testing. About 386 women from Belgium and Australia will be randomly assigned to use either a CGM or a regular glucomet…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This study tests whether a continuous glucose monitor (CGM) helps control blood sugar better than standard finger-stick checks for people with diabetes who are recovering at home through Mayo Clinic's Advanced Care at Home program. About 100 participants will use the Dexcom G6 PR…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study tests whether a diode laser, apple cider vinegar, or the herb Gymnema Sylvestre can better disinfect root canals in people with type 2 diabetes who have a tooth infection called apical periodontitis. Ninety participants will be split into groups receiving different com…

This study compares two types of IV fluids—saline and Ringer lactate—in 300 adults with severe diabetic ketoacidosis (DKA) admitted to the ICU. The goal is to see which fluid helps resolve DKA faster within 24 hours. Current guidelines recommend saline, but it may cause side effe…

This study compares two ways to place heart stents in people with diabetes: one using special imaging (IVUS or OCT) and the other using standard X-ray. The goal is to see if the imaging method reduces heart-related deaths, heart attacks, or the need for repeat procedures. About 1…

This study tests whether a radioactive drug called lutetium-177 oxodotreotide, when combined with a standard dose of octreotide, works better than a high dose of octreotide alone for people with advanced neuroendocrine tumors of the gut or pancreas. About 220 adults aged 18-75 wi…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study tests whether taking a probiotic called Desulfovibrio piger for 4 weeks can lower inflammation and help preserve the body's own insulin production in people who have had type 1 diabetes for more than 5 years. Twenty adults with remaining beta cell function will receive…

This study is testing a procedure called EUS-guided radiofrequency ablation (EUS-RFA) for people with pancreatic insulinoma, a rare tumor that causes low blood sugar. The procedure uses a thin needle passed through an endoscope to deliver heat and destroy the tumor. Researchers w…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study tests whether semaglutide, a diabetes drug, can help heal foot ulcers in people with type 2 diabetes. About 52 adults will receive either semaglutide or a placebo for 20 weeks. The main goal is to see if more ulcers heal completely with the drug. This is an early-phase…

This study explores whether spending time in the cold enough to shiver can improve how the body handles sugar in people with type 2 diabetes. Fifteen adults aged 40-75 with type 2 diabetes will undergo 10 days of cold exposure with shivering. Researchers will measure changes in i…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. Researchers will compare the drug to a placebo over 6 months in 16 participants. The main goal is to mea…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study compares two drugs, choline fenofibrate and policosanol, in 56 Korean adults with type 2 diabetes and high cholesterol who have early signs of artery plaque. The goal is to see if choline fenofibrate can reduce plaque buildup in the carotid artery, measured by 3D ultra…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study compares two diabetes medications, enavogliflozin and pioglitazone, when added to standard metformin treatment. It includes 120 adults with type 2 diabetes whose blood sugar is not well controlled. The goal is to see which drug works better at lowering blood sugar and …

This study tests whether community health workers can help women in urban slums of India get screened for type 2 diabetes after having gestational diabetes. 330 women will either receive home-based testing or a referral to a clinic, plus diabetes education. A smaller part of the …

This study compares two medications, clopidogrel and cilostazol, to see if they can slow down the buildup of plaque in the neck arteries of people with type 2 diabetes. The goal is to prevent future heart attacks and strokes. About 120 adults with diabetes and early signs of arte…

This study looks at whether adding omega-3 to a common statin (atorvastatin) can better reduce plaque buildup in the neck arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to get either atorvastatin plus omega-3 or atorvastat…

This early-stage trial is testing a new drug, HMS1005, in 40 people with type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Researchers will also look at how it affects blood sugar levels over 24 hours. Participants will receive either the…

This pilot study is testing whether a 12-week combination of two common diabetes drugs—dapagliflozin (Farxiga) and semaglutide (Ozempic)—is safe and helpful for people who have received a kidney transplant. The 20 participants will take both drugs and be monitored for changes in …

This study tests whether taking a prebiotic fibre supplement for 6 months can help people with type 1 diabetes have fewer dangerous low blood sugar episodes. Researchers will also see if it improves overall blood sugar control and gut health. The study involves 144 people aged 7 …

This study tests whether starting two diabetes drugs early—metformin plus either oral semaglutide or empagliflozin—controls blood sugar better than metformin alone in adults recently diagnosed with type 2 diabetes. About 90 participants will take the combination or just metformin…

This study is looking at how semaglutide, a drug used for diabetes and weight loss, changes the amount of fat stored inside the heart and leg muscles. Researchers want to see if semaglutide can shift fat away from these organs, which might improve health beyond just lowering bloo…

This study tests whether a total diet replacement of just 850 calories per day for 3 months, followed by weight maintenance, can help people with type 2 diabetes achieve remission. Participants are randomly assigned to follow-up via an eHealth app or in-person visits. The goal is…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This study tests a new drug called dorzagliatin in 44 adults with a rare, inherited form of diabetes (GCK-MODY). The drug works by activating a key enzyme to help the body better control blood sugar. Participants will receive both the drug and a placebo at different times to see …

This study tests whether using a continuous glucose monitor (CGM) for short periods, combined with personalized feedback, helps adults with type 2 diabetes control their blood sugar better than standard finger-prick testing. About 400 participants will be randomly assigned to eit…

This study tests whether a new combination drug works better than taking two separate medicines for people with both high blood pressure and type 2 diabetes. About 228 adults will take either the combo pill or a single-ingredient pill for 12 weeks. Researchers will check changes …

This Phase 2 trial tests HP-211, a botanical extract from common vegetables like endive and lettuce, in 300 people with type 2 diabetes. The goal is to see if it can improve how the body uses insulin and lower blood sugar levels over 90 days. Participants take HP-211 or a placebo…

This study tests a new drug, evexomostat, added to two standard treatments for a common type of advanced breast cancer (HR+, HER2-). The goal is to see if the triple combination is safe and can reduce high blood sugar side effects often caused by the standard drugs. About 52 adul…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study looks at whether changing the types of carbohydrates people with type 1 diabetes eat can improve blood sugar control. Researchers will compare a diet with more whole grains and beans to one with mostly refined grains. 80 adults will be monitored to see if the diverse c…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests tirzepatide, a medication already used for obesity, in 60 adults who have both type 1 diabetes and obesity. Participants will receive either tirzepatide or standard care to see if it helps with weight loss and is safe. The goal is to understand if this drug can b…

This early-phase trial tests a single infusion of genetically modified immune cells (CAR-T cells) designed to target and calm the immune attack that causes type 1 diabetes. Nine adults with early-stage type 1 diabetes will receive the cells and be monitored for safety, insulin ne…

This study tests whether a low-fat vegan diet and nutrition classes can improve health and lower medical costs for people with type 2 diabetes. Seven hundred Blue Cross Blue Shield subscribers will follow the diet for 16 weeks. Researchers will measure changes in weight, blood su…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This pilot study will enroll 150 pregnant individuals to see if a continuous glucose monitor (CGM) can accurately diagnose gestational diabetes. Participants will wear a small sensor on their arm that measures blood sugar continuously. The results will be compared to the standard…

This study is testing whether a diagnostic test called KidneyIntelX can help primary care doctors improve care for people with type 2 diabetes and chronic kidney disease. The test predicts the risk of kidney function worsening. Researchers will see if using this test leads to mor…

This study tests whether a continuous glucose monitor (CGM) worn on the arm can diagnose gestational diabetes as well as the standard oral glucose tolerance test (OGTT). Pregnant women of Chinese or Indian ethnicity will wear the sensor for up to 10 days and also undergo the OGTT…

This trial is testing whether an artificial intelligence (AI) model, called MONA DR, can accurately detect diabetic retinopathy—a common eye complication of diabetes that can lead to blindness—from retinal photographs. The study will enroll 100 adults with diabetes and compare th…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This trial evaluates a new continuous glucose monitoring (CGM) system in adults with type 1 diabetes. Participants will wear the sensor for 14 days while their blood sugar is measured against standard lab tests to see how accurate and safe the device is across different glucose l…

This study tests a small, noninvasive device that analyzes breath to detect high and low blood sugar events in children and young adults with diabetes. Participants aged 7–25 who already use a continuous glucose monitor will provide breath samples during normal, high, and low blo…

This study collects blood samples from healthy people, those with benign diseases, and cancer patients to develop a multi-analyte blood test. The test looks for DNA methylation markers that may indicate the presence of various cancers, especially liver cancer. Researchers aim to …

This study explores whether a simple finger-prick blood sugar test done during a routine dental visit can help find people with advanced gum disease who have undetected high blood sugar. Adults with severe periodontitis but no known diabetes will be tested at the dental clinic an…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study is testing a new laser-based blood test that uses nanoparticles to detect pancreatic cancer early. Researchers will enroll 400 people, including those with diabetes, pancreatic cysts, or pancreatic cancer, to see if the test can accurately identify cancer. The goal is …

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study is testing a new, non-invasive liver scan called iLivTouch to see if it can accurately detect a serious liver condition called MASH in people who have both type 2 diabetes and fatty liver disease. The scan measures liver inflammation, fat, and stiffness without any nee…

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants breathe into a portable analyzer that measures volatile organic compounds. The goal is to gather data to refine the dev…

This study tests a new radioactive imaging agent called 68Ga-HA-DOTATATE to see if it can safely and accurately detect neuroendocrine tumors using PET/CT scans. About 600 people with known or suspected tumors will receive the agent and be followed for one year. The goal is to imp…

This study tests whether a special PET scan using a radioactive tracer called FDOPA can accurately find and locate focal lesions in the pancreas of infants with congenital hyperinsulinism, a condition causing severe low blood sugar. The goal is to help surgeons remove only the di…

This study will enroll nearly 3,000 people with type 2 diabetes to improve how diabetic retinopathy (an eye disease) is diagnosed and managed. Researchers will use eye exams, blood tests, and continuous glucose monitors to build better models for predicting and treating the condi…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insu…

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. Thirty women will be split into three groups based on their current blood sugar levels. They will follow the die…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This trial tests a 4-week diet and exercise program called Small Steps for Big Changes in adults with prediabetes. Participants will attend supervised exercise sessions and learn to cut sugar and refined carbs while increasing vegetables. The study aims to see if this program can…

This trial compares two blood-thinning drugs—aspirin and cilostazol—to see which one better prevents major heart and blood vessel events in people with type 2 diabetes who are already at high risk. About 1,200 participants will be randomly assigned to take one of the two medicati…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study adapts a diabetes prevention program for Hispanic adolescents aged 12-16 with obesity, delivering it via telehealth using a Fitbit, chatbot, and online lessons. The goal is to see if this approach is feasible and acceptable for reducing type 2 diabetes risk. Researcher…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This pilot study tests whether a family-centered health and wellness coaching program can help prevent type 2 diabetes in South Asian and Black African/Caribbean families in Ontario, Canada. Each family dyad includes an adult caregiver and a youth aged 14–24. Participants receive…

This study is testing whether a digital tool that encourages self-reflection and healthy habits can prevent type 2 diabetes. Over 40,000 adults without diabetes will use the app or receive usual care for three years. Researchers will track how many people develop diabetes in each…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study tests whether a natural bile acid called 7-Ketolithocholic Acid, taken as a supplement, can lower blood sugar levels in 100 adults with prediabetes. Participants will also follow a healthy diet and exercise plan. The goal is to see if this supplement can help prevent o…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests whether a gamified education program can improve health literacy and quality of life in children aged 8-12 with type 1 diabetes. Half of the 52 participants will receive the gamified program plus standard education, while the other half gets standard education al…

This study tests whether eating protein and fat (scrambled eggs) before carbohydrates (toast) can reduce blood sugar spikes in women with gestational diabetes. Thirty-five pregnant women will eat the same breakfast in two different orders on separate days, acting as their own con…

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This pilot study tests a new flexible bandage called exciflex that delivers mild electrical stimulation to chronic wounds that won't heal normally. The study includes 16 veterans with diabetes or spinal cord injury who have lower leg wounds. The bandage is designed to work for up…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This Phase 3 trial tests whether the experimental drug paltusotine can reduce flushing and diarrhea in adults with carcinoid syndrome caused by neuroendocrine tumors. About 141 participants will receive either paltusotine or a placebo daily for 12 weeks. The study measures how mu…

This study looks at whether a common diabetes medication (GLP-1 RA) can improve muscle strength and bone health in women over 65 with type 2 diabetes. About 20 participants will take the drug as part of their regular care and undergo tests like grip strength and bone density scan…

This trial tests whether taking Ceylon cinnamon supplements for six months can reduce pain and improve blood sugar, cholesterol, and body weight in adults with painful diabetic peripheral neuropathy. Participants are randomly assigned to receive either cinnamon capsules or a plac…

This study looks at whether eating a small handful of almonds (about 18 grams) 30 minutes before a meal can reduce the rise in blood sugar after eating. Researchers will test 25 adults with prediabetes, comparing blood sugar levels after meals with and without almonds. They also …

This study investigates whether low-frequency pulsed electromagnetic field (PEMF) therapy can improve vibration perception and protective sensation in people with diabetic foot ulcers. Forty-two participants with type 2 diabetes and Wagner grade 1 ulcers will receive either real …

This study tests whether a supplement called Normast3 can reduce nerve pain and improve nerve function in adults with diabetic polyneuropathy, a common complication of diabetes. About 40 participants will take either Normast3 or a placebo twice daily for 12 weeks, while researche…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether pairing teens with type 1 diabetes with a young adult peer mentor can help them become more physically active and improve their quality of life. The 12-week program includes in-person, virtual, and text-based support. Researchers will measure how well the…

This study tests a group-based program called Supporting Teen Problem Solving (STePS) designed to reduce diabetes-specific emotional distress in teenagers with type 1 diabetes. The program is based on cognitive-behavioral and problem-solving approaches. Researchers will enroll 36…

This study compares a psychological therapy program called ACT1VATE to standard diabetes education in 250 adults with type 1 diabetes who have high emotional distress and poor blood sugar control. The therapy is delivered in five group sessions via video call. Researchers will me…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study looks at whether counseling sessions can help people with type 2 diabetes become more physically active and sit less. Researchers will compare standard care with informational sessions on exercise benefits, with or without practical guidance from a kinesiologist. The g…

This study tests whether natural cervical ripening methods can help labor start on its own in pregnant women with diet-controlled gestational diabetes. About 74 participants will try these methods starting at 37 weeks to see if they can avoid a medically induced labor. The goal i…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests whether soaking your feet in hot water for 12 weeks can improve blood sugar control and blood vessel function in adults with type 2 diabetes. Researchers will compare hot water foot baths to neutral temperature foot baths in 44 people aged 45-75. The goal is to s…

This study tests a special medical food powder (Encala®) in 18 adults with pancreatic cancer who have trouble absorbing fat, causing stomach issues and weight loss. The goal is to see if the powder is easy to take and helps improve fat absorption and quality of life. This is an e…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study tests whether taking 3 mg of melatonin each night for 8 weeks can improve sleep and daily body rhythms in people with diabetic retinopathy. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65 with type 2 diabetes and moderate eye damage. Th…

This study tests a group-based psychological program called ACTnow for emerging adults (ages 18-35) with type 1 diabetes who feel overwhelmed by their condition. The program includes six bi-weekly sessions led by a psychologist and nurse, focusing on mindfulness and acceptance st…

This study will test a new screening program for 3,000 people turning 50 in the Ascoli Piceno province of Italy. Participants will fill out questionnaires and get a blood test to check their risk of developing type 2 diabetes and cardiovascular disease. The goal is to see if this…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia), especially after fasting. Researchers will admit 1,500 adults to the NIH Clinical Center for controlled fasting and a series of blood tests to measure insulin and other fac…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This study is testing whether a continuous glucose monitor (CGM) can predict blood sugar problems in people who are at risk for type 1 diabetes but have no symptoms. Researchers will follow 75 people aged 5 to 39 who have diabetes-related autoantibodies. They will compare CGM dat…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study looks at whether tiny particles released by fat cells, called adiposomes, carry harmful fats that damage blood vessels in people with obesity and type 2 diabetes. Researchers will test if a 12-week aerobic exercise program or weight-loss surgery can reduce these harmfu…

This study looks back at medical records from 600 people to compare pancreatic neuroendocrine tumors (PanNETs) that appear at a younger age versus those that appear later in life. Researchers want to see if these two groups have different risk factors, tumor features, metabolic c…

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study is looking at whether a specific genetic variation, called SLC16A11, influences how well the common diabetes drug metformin lowers blood sugar. Adults with type 2 diabetes will be grouped by whether they carry this gene variant and will take extended-release metformin …

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. …

This study looks at how metabolic problems in type 2 diabetes might affect the way the brain and heart communicate. Researchers will measure brain activity, heart rhythm, physical fitness, and mental well-being in about 46 adults with type 2 diabetes. The goal is to see if these …

This study is for adults aged 18 to 55 who were diagnosed with type 1 diabetes within the last 6 months. Researchers want to see how many of them carry a specific gene called HLA-DRB1*04:01. Participants will provide a blood sample or cheek swab for genetic testing. The goal is t…

This study investigates whether a key channel in insulin-producing cells becomes less active as type 2 diabetes progresses. Researchers will give a single 10 mg dose of glipizide, a drug that blocks this channel, to people with and without type 2 diabetes and measure their insuli…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study explores whether stem cells from taste buds can be turned into insulin-making cells. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells in a lab. The goal is to see if this is possible in humans, which …

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study is checking if the diabetes medicine exenatide (Byetta, Bydureon) increases the risk of pancreatic cancer. Researchers will look at health records from 24,000 patients across seven European countries, comparing those who started exenatide with those who started other d…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This early-stage trial is testing how well different tablet versions of the experimental drug elecoglipron are absorbed by the body. Healthy volunteers receive a single dose of one formulation, and researchers measure drug levels in the blood over time. The goal is to compare the…

This study looks at whether measuring the amount of certain targeted cancer drugs in the blood can help find the best dose for each patient. It involves adults with advanced digestive cancers like colorectal, liver, and stomach tumors who are already taking these medications. By …

This pilot study is testing whether a real-time continuous glucose monitor (FreeStyle Libre 3) can reveal differences in blood sugar patterns between people with diabetes who have gastroparesis (delayed stomach emptying) and those without it. About 50 adults with type 1 or type 2…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at whether a standard blood test measurement called red cell distribution width (RDW) is linked to HbA1C levels in people with type 2 diabetes. Researchers will measure RDW and HbA1C in 250 adults with uncontrolled diabetes at the start, then again after 3 and 6 …

This early-phase trial investigates whether oxidative stress—an imbalance of damaging free radicals and protective antioxidants—causes small blood vessel dysfunction in otherwise healthy women who previously had gestational diabetes. Researchers will deliver two drugs (acetylchol…

This study is collecting blood, stool, genetic information, and health records from 1,200 Medicaid patients in South Carolina — some with type 2 diabetes and some without. Researchers will analyze this data to find patterns that could predict chronic kidney disease, a common comp…

This observational study uses a painless, non-invasive eye scan called iris OCTA to measure blood flow in the iris of people with type 2 diabetes. Researchers want to see if blood-flow patterns differ between healthy eyes, diabetic eyes without complications, and those with diabe…

This study reviews medical records of 400 adults aged 40-70 who were recently diagnosed with type 2 diabetes in five Southeast Asian countries. Researchers will look at health data from before and after diagnosis to understand how heart disease risk is distributed. No new treatme…

This observational study follows 1,000 pregnant people with type 1 diabetes who use either a commercial or an open-source automated insulin delivery (AID) system. Researchers aim to compare maternal and neonatal outcomes, blood sugar control, and emotional well-being between the …

This study investigates whether genetic differences influence how people respond to semaglutide, a GLP-1 drug used for weight loss and diabetes. Overweight or obese volunteers of Amish descent will receive weekly semaglutide injections for six weeks. Before and after treatment, r…

This study explores whether a person's psychological profile — Type A (competitive, ambitious) or Type B (relaxed, less stress-prone) — affects the healing of diabetic foot wounds. Researchers will compare Bortner questionnaire scores between people whose wounds heal and those wh…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study surveys adults taking GLP-1 medications (like semaglutide or tirzepatide) for diabetes or weight loss to understand their resistance training habits before and after starting the drug. The goal is to learn how often people strength train, what their workouts look like,…

This study tests how well the adhesive parts of a future patch pump stick to the skin of children aged 7 to 17 who need insulin for diabetes. The device is a dummy—it has no electronics and just mimics the shape and weight of a real pump. Researchers will see if the patch stays a…

This study compares quality of life and psychological factors—such as anxiety, depression, stress, and social support—between pregnant women with gestational diabetes and those without. Researchers will survey 206 women aged 20–40 in India using standard questionnaires. The goal …

This study looks at how different phases of the menstrual cycle affect blood glucose changes during exercise in women with type 1 diabetes who take oral contraceptives. Participants wear a continuous glucose monitor and complete a 45-minute aerobic exercise session during both th…

This study investigates how the diabetes medication empagliflozin influences the body's production of glucose, fats, and ketones in people with type 2 diabetes. Researchers will also test whether blocking the sympathetic nervous system with propranolol changes these effects. The …

This study investigates how the diabetes medication empagliflozin (an SGLT2 inhibitor) increases ketone production and fat breakdown in people with type 2 diabetes. Researchers will also test whether another drug, pioglitazone, can prevent these effects. The goal is to understand…

This study investigates why SGLT2 inhibitors, a common diabetes medication, can sometimes lead to ketoacidosis—a dangerous buildup of acids in the blood. Researchers suspect it only happens when patients also have low blood volume and low insulin levels. Adults with type 2 diabet…

This study compares walking patterns between people with diabetic peripheral neuropathy (nerve damage from diabetes) and healthy adults. It also tests whether giving people real-time feedback on their walking form can immediately change how they walk. The goal is to understand th…

This study measures four specific substances in saliva—apelin, chemerin, ghrelin, and lipocalin 2—in people with and without type 2 diabetes and gum disease. Researchers want to see if these substances are linked to the presence or severity of these conditions. The goal is to fin…

This study investigates whether proteins released by muscles, called myokines, can serve as early warning signs or even causes of muscle loss (sarcopenia) in people with metabolic or endocrine conditions like diabetes, obesity, and Cushing syndrome. Researchers will measure myoki…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study follows 1,000 adults with diabetes to find early signs that predict serious complications like nerve damage, eye disease, kidney problems, and heart issues. Researchers measure blood sugar control and other health markers over time. The goal is to develop better risk a…

This study looks at how blood sugar levels affect immune cells (monocytes) and kidney cells in people with type 1 diabetes and early chronic kidney disease. Researchers will compare participants with better versus worse blood sugar control to see if certain immune cells become mo…

This study is recruiting 3,000 adults with type 2 diabetes to collect basic health information and a small blood sample. The goal is to identify people who may be eligible for other clinical trials. No experimental treatment is given. Participants simply help researchers understa…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study investigates how two days of forearm immobilization (keeping the arm in a cast or sling) changes the way muscles take up glucose and amino acids. Researchers will compare these effects in people with type 2 diabetes and healthy volunteers. The goal is to understand why…

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study looks at how improving sleep regularity might help control blood sugar and reduce heart disease risk in adults with type 1 diabetes. Researchers will monitor 100 participants' sleep, blood sugar, and heart health markers. The goal is to understand the body clock's role…

This study investigates whether 6 weeks of treadmill walking with blood flow restriction cuffs on the legs can improve immune cell function in adults with type 2 diabetes. Participants walk three times per week, with some wearing inflatable cuffs that partially limit blood flow. …

This study looks at basic blood and clotting measures in children with type 1 diabetes compared to healthy children. Researchers want to see if diabetes causes changes in red blood cells or clotting that could lead to complications. The study involves children aged 1 month to 18 …

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study tests a program called SPARK-CGM that helps primary care clinics prescribe continuous glucose monitors (CGM) to people with diabetes. CGM devices track blood sugar in real-time, but they are underused in primary care. The program provides training, workflow support, an…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is testing whether mixed reality (using a Meta Quest 3 headset) can reliably measure walking ability, balance, and leg strength in people with type 2 diabetes. Researchers will compare the digital versions of three common physical tests (6-minute walk, timed up and go,…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study looks at how accurate continuous glucose monitors (CGMs) are in children and young adults with type 1 diabetes when they have surgery. Researchers will compare CGM readings to standard blood glucose tests during the procedure. The goal is to see if these devices can be…

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study is testing whether wearable devices like continuous glucose monitors and smart bracelets, combined with smartphone apps, can help predict and prevent complications in people with type 2 diabetes. Researchers will enroll 6,000 adults and follow them for 3 months, using …

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study tests whether a low-added-sugar, high-fat diet can reduce diabetes risk in adults with cystic fibrosis (CF). Sixty participants will receive either a low-sugar or standard CF diet for 8 weeks. Researchers will measure changes in insulin production, body fat, and blood …

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study follows 140 pregnant women who conceived while still breastfeeding. Researchers want to see if breastfeeding lowers the chance of developing gestational diabetes in the new pregnancy. They will track blood sugar levels and baby growth to find out.

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This early-stage study looks at how the body processes HRS9531 injection in people with mild or moderate liver issues compared to those with healthy livers. Researchers will measure drug levels and check for side effects in 24 participants. The goal is to understand if liver func…

This study is checking how accurate the Dexcom G7 continuous glucose monitor is for patients in the intensive care unit after major abdominal surgery or organ transplant. Researchers will place two sensors on each patient—one that is calibrated and used to guide insulin dosing, a…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study surveys 100 general practitioners in Italy to assess their knowledge of how oral health, especially gum disease, relates to systemic conditions like diabetes. Participants complete a 35-question digital questionnaire. The goal is to identify gaps in knowledge and impro…

This early-phase study looks at whether adding dapagliflozin, a diabetes drug, to standard chemotherapy changes insulin-related markers in the blood. It involves 20 women with early-stage HER2-negative breast cancer who also have high insulin levels. The goal is to gather safety …

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study looks at whether a substance in the blood called 1,5-anhydroglucitol can help measure how many insulin-making cells (beta cells) children with type 1 diabetes still have. Researchers will compare levels in 60 children with diabetes (newly diagnosed and long-term) to he…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers collect a small amount of belly fat during the operation and take blood samples afterward. The goal is to understand why some patient…

This study is testing whether a substance in the blood called 1,5-anhydroglucitol can serve as a marker for how well the pancreas is working in obese children, with or without type 2 diabetes. Researchers will measure levels of this marker in 50 children aged 12 to 16 and compare…

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study follows 296 Vietnamese adults with type 2 diabetes for one year to compare how insulin-producing beta cells change in people diagnosed before age 40 versus those diagnosed at 40 or older. Researchers will measure blood markers like C-peptide and HbA1C at 3, 6, 9, and 1…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study looks at whether a structured goal-setting program can help people with chronic conditions like high blood pressure, diabetes, or high cholesterol adopt healthier behaviors. Researchers will compare 600 participants who receive the program to those who get usual care. …

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study is observing 55 adolescents with type 1 diabetes to understand the many factors that influence their physical activity, from personal motivation to school and community support. Participants will wear an activity tracker for a week and complete questionnaires about the…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study looks at how well the pancreas can produce insulin in people with type 2 diabetes. Participants drink a meal replacement shake, and blood is taken five times over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin prod…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the normal function of HDL, or 'good' cholesterol. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 healthy people…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study looks at why people with type 2 diabetes often develop heart problems. Researchers will collect blood and urine from 90 volunteers—some with diabetes and heart disease, some with diabetes only, and some healthy—to study special cells called endothelial progenitor cells…

This study looks at how a drug called diazoxide, which activates certain brain centers, can change how much sugar the liver makes. People with type 2 diabetes often have livers that produce too much sugar, leading to high blood sugar. The study will involve 100 participants (both…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study looks at whether repeated eye injections of bevacizumab, a drug used for diabetic eye disease and other conditions, might affect heart health. Researchers will measure certain enzymes in the blood that are linked to heart disease risk. The study includes 180 adults age…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study looks at how certain diabetes medications (semaglutide, liraglutide, and tirzepatide) affect blood flow and oxygen use in the eyes of people with diabetes. Researchers will use special cameras to measure eye blood vessels and oxygen levels in 20 adults before and after…

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study aims to create a questionnaire that measures how actively people with type 2 diabetes manage their health. Researchers will test the tool with 600 patients and healthcare workers to ensure it is accurate and reliable. The goal is to better understand patients' behavior…

This study looks at 3,000 people with type 2 diabetes to see if certain signs of inflammation in the blood are linked to diabetes-related health problems. Researchers hope to find early clues that could help identify patients at higher risk for complications. The study is purely …

This study follows 800 pregnant women—some healthy, some with obesity or diabetes—to understand how these conditions affect both mother and baby during pregnancy and after birth. Researchers will track body composition, blood sugar, blood pressure, and other health markers throug…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study aims to better predict which kidney transplant patients who develop diabetes will later suffer serious complications like heart disease or kidney failure. Researchers will use machine learning and genetic analysis to find new markers in blood, urine, and kidney tissue.…

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…