Diabetes drug semaglutide may reshape fat in heart and muscles
NCT ID NCT07065383
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is looking at how semaglutide, a drug used for diabetes and weight loss, changes the amount of fat stored inside the heart and leg muscles. Researchers want to see if semaglutide can shift fat away from these organs, which might improve health beyond just lowering blood sugar. The study will involve 60 adults with type 2 diabetes who are not very active, and they will receive semaglutide along with diet advice and either general physical activity encouragement or a supervised exercise program.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Semaglutide
- What this could lead to
- If successful, this could show that semaglutide helps rebalance fat storage in the heart and muscles, potentially leading to better diabetes management and reduced cardiovascular risk.
- What could go wrong
- This is a small, early-stage study (60 participants) focused on measuring fat changes, not clinical outcomes. The results may not apply to all people with type 2 diabetes, and semaglutide can cause side effects like nausea and vomiting.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Cardiac Research Office, Aberdeen Royal Infirmary
RECRUITINGAberdeen, Aberdeenshire, AB25 2ZD, United Kingdom
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