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Could a Low-Energy diet reverse type 2 diabetes in teens?

NCT ID NCT06572345

Recruiting now Disease control Sponsor: Nottingham University Hospitals NHS Trust Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study explores whether a short-term low-energy diet (using meal replacements) can help adolescents aged 12–17 with obesity and type 2 diabetes lose weight and potentially achieve diabetes remission. Participants follow the diet for 12 weeks, then gradually reintroduce food over 12 weeks, followed by 28 weeks of weight maintenance. The trial also interviews participants and healthcare providers to understand what helps or hinders success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
low-energy diet (meal replacements)
What this could lead to
If successful, this approach could offer a non-drug way to reverse type 2 diabetes in teenagers with obesity, reducing the need for lifelong medication.
What could go wrong
This is a small feasibility study, not a large trial. The diet is very restrictive and may be hard to stick with, and long-term weight maintenance is uncertain.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Pediatric Obesity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC OBESITY TYPE 2 DIABETES

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Nottingham University Hospital NHS Trust

    RECRUITING

    Nottingham, NG7 2UH, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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