New pill aims to tame flushing and diarrhea in rare cancer syndrome

NCT ID NCT07087054

Recruiting now Symptom relief Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether the experimental drug paltusotine can reduce flushing and diarrhea in adults with carcinoid syndrome caused by neuroendocrine tumors. About 141 participants will receive either paltusotine or a placebo daily for 12 weeks. The study measures how much symptoms improve compared to a placebo group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paltusotine
What this could lead to: If it works, this could provide a new daily pill to better control flushing and diarrhea in people with carcinoid syndrome.
What could go wrong: This is a Phase 3 trial, but it's still testing if paltusotine works better than placebo. Results may not confirm benefit, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoid syndrome carcinoid tumor cecum neuroendocrine tumor G1 enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor ileal neuroendocrine tumor G1 intestinal neuroendocrine tumor G1 liver neuroendocrine carcinoma neuroendocrine neoplasm serotonin syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOID CARCINOID INTESTINE TUMOR CARCINOID SYNDROME CARCINOID SYNDROME DIARRHEA CARCINOID TUMOR CARCINOID TUMOR OF CECUM CARCINOID TUMOR OF ILEUM CARCINOID TUMOR OF LIVER CARCINOID TUMOR OF PANCREAS

Contacts and locations

Locations

AC Camargo Cancer Center
RECRUITING

São Paulo, Brazil, 01509-010, Brazil
APHM- Hopital de la Timone
RECRUITING

Marseille, 13005, France
Asklepios Kilnic St. Georg
RECRUITING

Hamburg, 20099, Germany
Associacao Hospitalar Moinhos de Vento
RECRUITING

Porto Alegre, 90560-032, Brazil
Azienda Ospedaliero Universitaria Citta Della Salute E Della Scienza Di Torino
RECRUITING

Turin, 10126, Italy
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
CECIM-Centro de Estudios Cliicos e Investigaciones Medicas
RECRUITING

Santiago, 8320000, Chile
CHRU Tours - Hopital Trousseau
RECRUITING

Chambray-lès-Tours, 37170, France
CHU Bordeaux - Hopital Haut-Leveque
RECRUITING

Pessac, 33600, France
Centre Antoine Lacassagne
RECRUITING

Nice, 06100, France
Centre Hospitalier Universitaire Nantes
RECRUITING

Nantes, 44093, France
Centro de Endocrinologia y Diabetes Dr. A. Gutman ICM - Investigaciones
RECRUITING

Buenos Aires, C1425BGH, Argentina
Centro de Oncologia de Precision
RECRUITING

Santiago, Chile, 7560908, Chile
Centro de Oncolégica VIVA
RECRUITING

Mexico City, 06760, Mexico
Centrum Diagnostyczno-Lecznicze ,,GAMMED"
RECRUITING

Warsaw, 02-351, Poland
Clinical Universidad Catolica del Maule, Ltda
RECRUITING

Maule, Chile, 3460000, Chile
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, 00136, Italy
Fundacao PIO XII - Hospital de Amor Barretos
RECRUITING

Barretos, 14784-400, Brazil
Fundacion Jimenez Diaz University Hospital
RECRUITING

Madrid, 28040, Spain
Health Pharma Professional Research S.A de C.V.
RECRUITING

Mexico City, 03100, Mexico
Henry Ford Cancer - Detroit
RECRUITING

Detroit, Michigan, 48202, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Hopital Beaujun - APHP
RECRUITING

Clichy, 92110, France
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario San Ignacio
RECRUITING

Bogotá, DC, 110231, Colombia
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo
RECRUITING

Buenos Aires, 1264, Argentina
Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo
RECRUITING

CABA, 1264, Argentina
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Institute of Oncology "Prof. Dr. Ion Chiricuta" Cluj Napoca
RECRUITING

Cluj-Napoca, 400015, Romania
Institute of Oncology Bucharest
RECRUITING

Bucharest, 022328, Romania
Instituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Instituto Médico Especializado Alexander Fleming
RECRUITING

Buenos Aires, C1426ANZ, Argentina
Instituto Médico de la Fundación Estudios Clínicos
RECRUITING

Santa Fe, 2000, Argentina
Instituto Nacional de Cancer (INCA)
RECRUITING

Rio de Janeiro, 20230-130, Brazil
Instituto Nacional de Cancerologia
RECRUITING

Bogotá, DC, 110411, Colombia
King's College Hospital
RECRUITING

London, UK, SE59RS, United Kingdom
Louisiana State University Health Sciences
RECRUITING

Metairie, Louisiana, 70006, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconcin
RECRUITING

Milwaukee, Wisconsin, 53222, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
NIHR Clinical Research Facility, Royal Hallamshire Hospital
RECRUITING

Sheffield, S102JF, United Kingdom
Nucleo de Pesquisa e Desenvolvimento de Medicamentos (MPDM)
RECRUITING

Fortaleza, 60430-275, Brazil
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, UK, OX37LE, United Kingdom
Queen Elizabeth Hospital Brimingham
RECRUITING

Birmingham, B15 2TH, United Kingdom
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Sanatorio Guemes
WITHDRAWN

Buenos Aires, C1180AAX, Argentina
Sociedade Literaria e Caritativa Santos Agostinho - Hospital Sao José
RECRUITING

Criciúma, 88811-000, Brazil
The Beatson WOS Cancer Centre
RECRUITING

Glasgow, G120YN, United Kingdom
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO166YD, United Kingdom
University Hospital of Wales
RECRUITING

Cardiff, CF144XW, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Virginia Comprehensive Cancer Center
RECRUITING

Charlottesville, Virginia, 22903, United States
Universitätsklinikum Marburg (UKGM)
RECRUITING

Marburg, 35043, Germany
Uniwersyteckie Centrum Kliniczne im. Prof K. Gibinskiego Slaskiego Uniwersytetu Medycznego w Katowicach
RECRUITING

Katowice, 40-154, Poland
Winshop Cancer Institute - Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Wokskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Centrum Wsparcia Badań Klinicznych
RECRUITING

Warsaw, 04-141, Poland
Yale University - New Haven Hospital - Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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