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New pill aims to tame flushing and diarrhea in rare cancer syndrome

NCT ID NCT07087054

Recruiting now Symptom relief Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether the experimental drug paltusotine can reduce flushing and diarrhea in adults with carcinoid syndrome caused by neuroendocrine tumors. About 141 participants will receive either paltusotine or a placebo daily for 12 weeks. The study measures how much symptoms improve compared to a placebo group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

paltusotine

What this could lead to

If it works, this could provide a new daily pill to better control flushing and diarrhea in people with carcinoid syndrome.

What could go wrong

This is a Phase 3 trial, but it's still testing if paltusotine works better than placebo. Results may not confirm benefit, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

carcinoid syndrome carcinoid tumor cecum neuroendocrine tumor G1 enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor ileal neuroendocrine tumor G1 intestinal neuroendocrine tumor G1 liver neuroendocrine carcinoma neuroendocrine neoplasm serotonin syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOID CARCINOID INTESTINE TUMOR CARCINOID SYNDROME CARCINOID SYNDROME DIARRHEA CARCINOID TUMOR CARCINOID TUMOR OF CECUM CARCINOID TUMOR OF ILEUM CARCINOID TUMOR OF LIVER CARCINOID TUMOR OF PANCREAS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AC Camargo Cancer Center

    RECRUITING

    São Paulo, Brazil, 01509-010, Brazil

  • APHM- Hopital de la Timone

    RECRUITING

    Marseille, 13005, France

  • Associacao Hospitalar Moinhos de Vento

    RECRUITING

    Porto Alegre, 90560-032, Brazil

  • Banner MD Anderson Cancer Center

    RECRUITING

    Gilbert, Arizona, 85234, United States

  • CECIM-Centro de Estudios Cliicos e Investigaciones Medicas

    RECRUITING

    Santiago, 8320000, Chile

  • CHRU Tours - Hopital Trousseau

    RECRUITING

    Chambray-lès-Tours, 37170, France

  • CHU Bordeaux - Hopital Haut-Leveque

    RECRUITING

    Pessac, 33600, France

  • Centre Antoine Lacassagne

    RECRUITING

    Nice, 06100, France

  • Centre Hospitalier Universitaire Nantes

    RECRUITING

    Nantes, 44093, France

  • Centro de Endocrinologia y Diabetes Dr. A. Gutman ICM - Investigaciones

    RECRUITING

    Buenos Aires, C1425BGH, Argentina

  • Centro de Oncologia de Precision

    RECRUITING

    Santiago, Chile, 7560908, Chile

  • Centro de Oncolégica VIVA

    RECRUITING

    Mexico City, 06760, Mexico

  • Clinical Universidad Catolica del Maule, Ltda

    RECRUITING

    Maule, Chile, 3460000, Chile

  • Fundacao PIO XII - Hospital de Amor Barretos

    RECRUITING

    Barretos, 14784-400, Brazil

  • Henry Ford Cancer - Detroit

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hoag Memorial Hospital Presbyterian

    RECRUITING

    Newport Beach, California, 92663, United States

  • Hopital Beaujun - APHP

    RECRUITING

    Clichy, 92110, France

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Ramon y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario San Ignacio

    RECRUITING

    Bogotá, DC, 110231, Colombia

  • Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo

    RECRUITING

    Buenos Aires, 1264, Argentina

  • Hospital of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Huntsman Cancer Institute, University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Instituto Médico Especializado Alexander Fleming

    RECRUITING

    Buenos Aires, C1426ANZ, Argentina

  • Instituto Médico de la Fundación Estudios Clínicos

    RECRUITING

    Santa Fe, 2000, Argentina

  • Instituto Nacional de Cancer (INCA)

    RECRUITING

    Rio de Janeiro, 20230-130, Brazil

  • Instituto Nacional de Cancerologia

    RECRUITING

    Bogotá, DC, 110411, Colombia

  • King's College Hospital

    RECRUITING

    London, UK, SE59RS, United Kingdom

  • Louisiana State University Health Sciences

    RECRUITING

    Metairie, Louisiana, 70006, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Medical College of Wisconcin

    RECRUITING

    Milwaukee, Wisconsin, 53222, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • NIHR Clinical Research Facility, Royal Hallamshire Hospital

    RECRUITING

    Sheffield, S102JF, United Kingdom

  • Nucleo de Pesquisa e Desenvolvimento de Medicamentos (MPDM)

    RECRUITING

    Fortaleza, 60430-275, Brazil

  • Oxford University Hospitals NHS Foundation Trust

    RECRUITING

    Oxford, UK, OX37LE, United Kingdom

  • Queen Elizabeth Hospital Brimingham

    RECRUITING

    Birmingham, B15 2TH, United Kingdom

  • Royal Free Hospital

    RECRUITING

    London, NW3 2QG, United Kingdom

  • Sanatorio Guemes

    WITHDRAWN

    Buenos Aires, C1180AAX, Argentina

  • Sociedade Literaria e Caritativa Santos Agostinho - Hospital Sao José

    RECRUITING

    Criciúma, 88811-000, Brazil

  • The Beatson WOS Cancer Centre

    RECRUITING

    Glasgow, G120YN, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    RECRUITING

    Southampton, SO166YD, United Kingdom

  • University Hospital of Wales

    RECRUITING

    Cardiff, CF144XW, United Kingdom

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University of Iowa Health Care

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Kentucky Medical Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Virginia Comprehensive Cancer Center

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Winshop Cancer Institute - Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Yale University - New Haven Hospital - Yale Cancer Center

    RECRUITING

    New Haven, Connecticut, 06510, United States