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New valve implant offers hope for rare heart condition

NCT ID NCT05064514

Ongoing Disease control Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a custom-made artificial heart valve, called TRICENTO, in 15 people with carcinoid heart disease who have severe leakage of the tricuspid valve and cannot have surgery. The valve is delivered through a catheter, avoiding open-heart surgery. The goal is to see if it reduces valve leakage and improves symptoms and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
TRICENTO valved stent graft (a custom-made artificial heart valve delivered through a catheter)
What this could lead to
If it works, this could offer a less invasive treatment option for people with carcinoid heart disease who have severe valve leakage and cannot undergo open-heart surgery.
What could go wrong
This is a very early, small study with only 15 participants, so results may not apply to everyone. The procedure carries risks like any heart implant, and the valve may not work as intended or could cause complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoid heart disease carcinoid syndrome carcinoid tumor serotonin syndrome tricuspid valve disorder tricuspid valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOID HEART DISEASE CARCINOID SYNDROME TRICUSPID REGURGITATION TRICUSPID VALVE DISEASE

Contacts and locations

Locations

  • Barts Health NHS Trust

    London, England, E1 1BB, United Kingdom

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