A new Catheter-Based valve could fix a leaky heart valve without surgery
NCT ID NCT06183684
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study aims to see if the device can be safely implanted and whether it reduces the backward flow of blood. Participants are adults aged 18 to 90 with severe or worse tricuspid regurgitation despite medical therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, placed through a catheter to replace the tricuspid valve without open-heart surgery
- What this could lead to
- If it works, this could offer a less invasive treatment option for people with severe tricuspid regurgitation who cannot have open-heart surgery.
- What could go wrong
- This is an early feasibility study with only 65 participants, so the device may not be safe or effective in the long run. Risks include complications from catheter-based valve replacement, such as bleeding, infection, or device failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kaiser Permanente
RECRUITINGSan Francisco, California, 94118, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-••••
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Montefiore Medical Center
RECRUITINGThe Bronx, New York, 10641, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oklahoma Heart Institute
RECRUITINGTulsa, Oklahoma, 74104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Piedmont Hospital
RECRUITINGAtlanta, Georgia, 30309, United States
Contact Phone: •••-•••-••••
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Providence Heart Institute
RECRUITINGPortland, Oregon, 97225, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tucson Medical Center
RECRUITINGTucson, Arizona, 85712, United States
Contact Email: •••••@•••••
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University Hospitals, Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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