Exercise and a diabetes drug: a One-Two punch for blood vessels?

NCT ID NCT03883412

Recruiting now Disease control Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether 16 weeks of exercise training, liraglutide treatment, or both can improve blood vessel function and insulin sensitivity in adults with type 2 diabetes. Participants are randomly assigned to one of three groups and are studied before and after the intervention. The study measures changes in capillary blood volume, artery flexibility, and how well insulin works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exercise training and/or liraglutide (a GLP-1 receptor agonist drug)
What this could lead to: If successful, this could point toward better non-insulin strategies to improve blood vessel function and insulin action in type 2 diabetes.
What could go wrong: This is a relatively small, 16-week study, so results may not be definitive or apply to all people with diabetes. Liraglutide can cause gastrointestinal side effects, and exercise may be challenging for some participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for TYPE2 DIABETES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE2 DIABETES

Contacts and locations

Locations

University of Virginia
RECRUITING

Charlottesville, Virginia, 22906, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.