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New shot may lower heart risk in patients whose medications block statins

NCT ID NCT06865885

Recruiting now Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This trial tests whether inclisiran, an injectable medication, can lower LDL cholesterol in patients who have multiple health conditions and take many drugs that interfere with standard statin therapy. Participants must be taking five or more prescription medications and have conditions like diabetes, kidney disease, or autoimmune disorders. The study compares inclisiran plus usual care to usual care alone over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
inclisiran
What this could lead to
If successful, inclisiran could offer a new way to lower LDL cholesterol in patients who cannot take high-dose statins due to drug interactions.
What could go wrong
This is a small, early-phase trial (100 participants) and may not show significant LDL reduction or long-term safety. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOMETABOLIC SYNDROME DRUG INTERACTIONS LDL-CHOLERSTEROL LOWERING PRIMARY PREVENTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UC San Diego Altman Clinical and Translational Research Institute

    RECRUITING

    La Jolla, California, 92037, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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