Proton beam plus chemo: a new hope for pancreatic cancer?
NCT ID NCT03652428
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with a precise type of radiation called proton therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose of the chemo drugs when given with the radiation. Participants will receive proton therapy daily for three weeks and chemo once a week during that time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Gemcitabine and nab-paclitaxel (chemotherapy drugs) plus proton radiation therapy
What this could lead to
If successful, this could lead to a more effective treatment option for locally advanced pancreatic cancer that may shrink tumors and improve survival.
What could go wrong
This is an early-phase trial with only 24 participants, so results may not apply broadly. The combination of chemo and radiation can cause significant side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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MedStar Georgetown University Hospital
RECRUITINGWashington D.C., District of Columbia, 20007, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland Medical Center/Maryland Proton Treatment Center
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact