New drug combo aims to tackle pancreatic cancer in patients with inherited gene mutations
NCT ID NCT01585805
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) can shrink tumors or slow cancer growth in people with advanced pancreatic cancer who have BRCA1, BRCA2, or PALB2 gene mutations. The study has two parts: one compares the combination to chemotherapy alone, and the other tests veliparib by itself in patients who have already received treatment. Researchers are looking at tumor response rates and how long patients live without their cancer getting worse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
veliparib (a PARP inhibitor) combined with gemcitabine and cisplatin chemotherapy
What this could lead to
If successful, this could point toward a more effective treatment option for pancreatic cancer patients with specific genetic mutations (BRCA/PALB2).
What could go wrong
This is a small, early-phase (phase II) trial with only 83 participants. The drug combination may not improve outcomes and could cause additional side effects like bone marrow suppression or fatigue.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Chaim Sheba Medical Center
Tel Litwinsky, 52621, Israel
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Ingalls Memorial Hospital
Harvey, Illinois, 60426, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Mercy Hospital Saint Louis
St Louis, Missouri, 63141, United States
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Shaare Zedek Medical Center
Jerusalem, 91031, Israel
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University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States