Could a nerve zap stop cancer wasting? early trial tests device for cachexia
NCT ID NCT07700212
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a device that blocks signals from the vagus nerve can safely help patients with metastatic pancreatic cancer who are experiencing severe weight loss (cachexia). The device is placed on the skin over the nerve and is used alongside chemotherapy. The main goal is to check for side effects and see if it might help control the wasting process.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- OnVagus device (transcutaneous low-frequency vagal nerve blockade)
- What this could lead to
- If safe and effective, this approach could offer a new way to prevent or reverse cancer-related wasting, improving strength and quality of life for patients.
- What could go wrong
- This is a very early, small phase 1 trial focused on safety, not proof of benefit. The device may cause side effects or fail to stop weight loss.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UT MD Anderson
Houston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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