New combo therapy targets Hard-to-Treat HER2 cancers
NCT ID NCT05372614
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This early-phase trial tests the safety and best dose of two drugs—neratinib and trastuzumab deruxtecan—given together to people with advanced solid tumors that have HER2 gene changes. The goal is to see if the combination can shrink tumors that have spread or can't be removed by surgery. About 33 adults with metastatic or unresectable cancers will take part.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Antelope Valley
RECRUITINGLancaster, California, 93534, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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City of Hope South Pasadena
RECRUITINGSouth Pasadena, California, 91030, United States
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City of Hope Upland
RECRUITINGUpland, California, 91786, United States
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City of Hope at Irvine Lennar
RECRUITINGIrvine, California, 92618, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
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UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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