Chilled water may curb pancreatitis risk after Bile-Duct procedure

NCT ID NCT07738094

Recruiting now Prevention Sponsor: Instituto do Cancer do Estado de São Paulo Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether rinsing the bile-duct opening with ice-cold water, on top of standard anti-inflammatory medication, can lower the chance of pancreatitis after an ERCP procedure. About 462 adults who need an ERCP will receive either the usual NSAID pill alone or the NSAID plus a cold-water rinse. The goal is to see if the cold-water addition reduces the rate of post-procedure pancreatitis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: irrigation of the duodenal papilla with ice-cold distilled water plus rectal indomethacin (NSAID)
What this could lead to: If it works, this simple, low-cost addition could significantly reduce the risk of pancreatitis after a common bile-duct procedure.
What could go wrong: This is a single-center trial, and the ice-water technique has not been tested alongside standard NSAID care. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATITIS, ACUTE

Contacts and locations

Locations

Serviço de Endoscopia Gastrointestinal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brasil.
RECRUITING

São Paulo, São Paulo, 05403-000, Brazil

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