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Can a simple scope procedure stop recurrent pancreatitis? SHARP trial results are in

NCT ID NCT03609944

Completed Prevention Sponsor: Oregon Health and Science University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a procedure called ERCP with sphincterotomy can lower the risk of repeat pancreatitis attacks in people with pancreas divisum, a condition where the pancreas ducts don't join normally. 181 adults who had at least two pancreatitis episodes were randomly assigned to get the real procedure or a sham procedure. Researchers tracked participants for up to 48 months to see if the procedure reduced the number of future pancreatitis attacks.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis chronic pancreatitis idiopathic chronic pancreatitis Pancreas Divisum pancreatitis recurrent acute pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREAS DIVISUM PANCREAS INFLAMED PANCREATITIS PANCREATITIS IDIOPATHIC PANCREATITIS, ACUTE

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Cedars-Sinai

    Los Angeles, California, 90048, United States

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Health Sciences Centre

    Winnipeg, Manitoba, R3A 1R9, Canada

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29407, United States

  • Methodist Dallas Medical Center

    Dallas, Texas, 75203, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Oregon Health and Science University

    Portland, Oregon, 97202, United States

  • Saint Luke's Hospital System

    Kansas City, Missouri, 64111, United States

  • The Ohio State University - Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • UCSF Medical Center

    San Francisco, California, 94143, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Rochester

    Rochester, New York, 14627, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • Virginia Mason Hospital & Seattle Medical Center

    Seattle, Washington, 98101, United States

  • Yale School of Medicine

    New Haven, Connecticut, 06520, United States

More trials for these conditions

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