Oregon Health And Science University

This study aims to find the best surgical treatment for children with obstructive sleep apnea who have small tonsils. Researchers will compare a new, personalized surgical plan based on a detailed sleep scan against the standard surgery of removing the tonsils and adenoids. The g…

This study is testing whether a medication called guselkumab can help heal painful skin ulcers caused by pyoderma gangrenosum, a rare inflammatory skin condition. Seventeen adult participants will receive guselkumab injections every four weeks along with a stable daily dose of pr…

This study is testing whether wearable sensors that give real-time audio or visual feedback during physical therapy can improve balance and walking recovery for people with mild traumatic brain injury (concussion). It will compare this high-tech approach to standard balance thera…

This study tests whether a newer, more focused type of deep brain stimulation can better control essential hand tremor than the standard type. Researchers will compare how well each method reduces shaking while trying to avoid side effects like slurred speech or balance problems.…

This study is testing whether adding counseling and a community peer navigator to standard medication treatment helps people with opioid addiction and other health problems stay in treatment and engage more with their primary care. Researchers will compare this enhanced 'MOUD Plu…

This study is testing if a personalized surgical approach works better than the standard surgery for treating obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will use a special sleep scope to see exactly where a child's airway is blocked and then plan a …

This large study is testing if changing the standard treatment order for cardiac arrest can save more lives. It will see if giving a medication called amiodarone one step earlier than current guidelines helps restore a normal heart rhythm faster. The goal is to improve survival a…

This study aims to find out which of two common hormone treatments works better to control heavy menstrual bleeding in adolescents and young adults who have an inherited bleeding disorder. Researchers will follow 300 participants aged 10-24 for six months to see how well an intra…

This study is testing a laser procedure to strengthen the cornea and improve vision in people with keratoconus, a condition where the cornea thins and bulges. Researchers will use advanced imaging to guide the laser treatment more precisely. The main goal is to see how much visio…

This study is testing a new type of eye scan called OCT angiography to see if it can better tell harmless iris tumors apart from cancerous ones. Researchers will compare the new scan results to the current standard method in 100 people, including those with iris tumors and health…

This study is testing whether a special eye imaging technology called OCT can help doctors fit scleral contact lenses better for people with irregular corneas, such as those with keratoconus or after certain eye surgeries. Researchers will compare the fit of lenses chosen using t…

This study aims to improve how doctors detect, monitor, and treat irregular corneas, which can cause blurry vision. Researchers will use a special, detailed eye scan called OCT to create a better system for classifying these conditions and guiding a laser treatment. The goal is t…

This study is testing whether a home physical therapy program helps people recover better from endometriosis surgery. Researchers will compare patients doing guided home exercises after surgery to those receiving standard post-op care. The goal is to see if the exercises improve …

This study is testing whether women with overactive bladder in rural Oregon can successfully use a simple, at-home nerve stimulation device to manage their symptoms. Participants will use a small electrical stimulator on their ankle three times a week for 12 weeks. The research a…

This study is testing a video-based support program called STELLA-FTD, designed to help family caregivers of people with frontotemporal dementia (FTD). The program connects caregivers in small online groups over 8 weeks to teach skills for managing difficult behaviors and accessi…

This study is testing whether a freezing treatment (cryoablation) works better than standard steroid injections for reducing pain from Morton's neuroma, a common and painful nerve problem in the ball of the foot. It's for adults whose pain hasn't gotten better with shoe inserts o…

This study is testing whether lidocaine injections into the abdominal wall can relieve chronic pain caused by a trapped nerve. Researchers will follow 45 adults with this condition for 12 weeks after their injection, which is part of their normal care. The main goal is to see if …

This study is testing an online training program called STELLA-R, designed to help family caregivers of people with dementia. The program teaches caregivers a practical method to understand and manage challenging behaviors like agitation or confusion. Researchers want to see if t…

This study aims to understand how eating a high-fat diet affects your body's internal clock and its ability to adjust to schedule changes. Researchers will compare how quickly healthy participants' biological rhythms adapt when eating high-fat versus low-fat meals during controll…

This study aims to better understand corneal swelling in Fuchs' dystrophy using special imaging technology. Researchers will measure how much the cornea swells in 60 participants with this eye condition. The goal is to predict how vision might change after surgical treatment by t…

This study is testing a new imaging tracer called Iodine-124 evuzumitide (AT-01) to see if it can create better pictures of where harmful amyloid proteins build up in the body, especially in the heart. Researchers will scan 150 patients with systemic amyloidosis using PET/MRI or …

This study aims to see if a special, non-invasive eye scan can detect changes in the retina linked to dementia. Researchers will compare scans from 20 people with mild dementia to scans from people without dementia. The goal is to find new ways to identify the disease by looking …

This study aims to understand how sleep and the body's natural daily rhythms affect blood pressure in people with high blood pressure. Researchers will observe 32 adults with hypertension in both home and controlled lab settings, measuring sleep patterns, heart activity, and stre…

This study aims to understand how a new wrist-worn device that provides gentle, rhythmic taps (called tactile cueing) affects walking and brain activity in people with Parkinson's disease. Researchers will enroll 60 participants to test if these personalized cues can make walking…

This study aims to understand if having a more regular sleep schedule improves markers of heart, blood vessel, and metabolic health. Researchers will ask healthy adults and a subgroup with chronic pain to keep a consistent bedtime for 12 weeks. They will measure changes in blood …

This study aims to understand how cervical mucus changes throughout the menstrual cycle and how it is affected by a hormone-blocking medication. Researchers will enroll 15 healthy participants with regular cycles to collect blood, mucus, and tissue samples at four specific times.…

This study aims to develop a tool to predict placental insufficiency, a condition where the placenta doesn't work properly, which can lead to stillbirth and other serious pregnancy complications. Researchers will follow 640 pregnant participants through their pregnancies, using u…