Oregon Health And Science University

This study tests giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest with a shockable rhythm. Researchers want to see if this speeds up treatment and improves survival. About 585 adults will take part, comparing the new timing to standard car…

This study tests whether a sugar called L-fucose can improve movement problems in adults with GLUT1 deficiency syndrome, a rare genetic disorder that affects brain energy. Sixteen participants will receive both the supplement and a placebo in random order, without knowing which t…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsillectomy for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery often fails. …

This study looks at whether adding addiction counseling and a community peer guide to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep up with doctor visits. About 70 adults with opioid dependence and other medical or so…

This study tests whether a personalized surgery guided by a sleep endoscopy works better than standard tonsil removal for children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. About 240 children will be randomly assigned to one of the two surgeries…

This study tests a laser-based corneal cross-linking procedure to improve vision in 100 people with keratoconus, a condition that thins and bulges the cornea. The treatment uses OCT imaging to guide the laser precisely. The main goal is to see how much vision improves 6 months af…

This study tests if guselkumab can heal painful skin ulcers in adults with pyoderma gangrenosum, a rare condition. 17 participants will receive the drug and be checked at 6, 16, and 32 weeks. The main goal is complete wound healing by week 32.

This study looks at two common hormonal treatments—a hormonal IUD and a daily pill—to see which works better for heavy menstrual bleeding in people aged 10 to 24 with inherited bleeding disorders like von Willebrand disease. Researchers will track bleeding, satisfaction, and qual…

This study is testing a special radioactive tracer called I-124 evuzumitide to see if it can improve diagnosis of cardiac amyloidosis, a condition where abnormal proteins build up in the heart. About 150 adults with known or suspected amyloidosis will get a PET/MRI scan after rec…

This study aims to improve how doctors detect and treat irregularly shaped corneas caused by conditions like keratoconus, dry eye, and scars. Researchers will use a special imaging technique called optical coherence tomography (OCT) to create a better classification system and gu…

This study tests a short sleep program for children aged 3-7 who have trouble falling asleep on their own. The program is given by a behavioral health consultant during regular doctor visits and includes sleep hygiene tips and a "Bedtime Pass." The goal is to see if the program i…

This study tests whether women living in rural areas can use a small, at-home nerve stimulation device to manage overactive bladder symptoms. About 38 women will try the treatment and report how it affects their quality of life and bladder control. The goal is to see if this appr…

This study tests whether freezing the nerve (cryoablation) along with a steroid and lidocaine injection works better than the injection alone for Morton's neuroma, a painful foot condition. About 32 adults who have not improved with simple treatments like orthotics will be enroll…

This study is testing an online program called STELLA-R that helps people caring for a family member with dementia. The program teaches a simple technique to understand and manage upsetting behaviors. About 238 care partners from Oregon, Washington, and Idaho will take part. The …

This study tests a video-based program called STELLA-FTD for family members caring for a loved one with frontotemporal dementia (FTD). The program helps caregivers manage difficult behaviors and connect with support resources. Researchers will measure changes in caregiver stress …

This study tests a newer type of deep brain stimulation (DBS) that directs electrical pulses more precisely, compared to standard DBS, for people with essential tremor. The goal is to see if the directional approach can better control hand tremors while causing fewer problems wit…

This study compares a home pelvic floor physical therapy program to standard post-surgery care for 30 women having endometriosis excision (without hysterectomy). The goal is to see if the home program improves pelvic pain, bladder/bowel symptoms, and overall quality of life durin…

This study tests whether wearable sensors that give real-time feedback during physical therapy can help people with mild traumatic brain injury (concussion) recover balance and movement better than standard therapy. Researchers will enroll 100 adults aged 18-60 who are still havi…

This study looks at whether injecting lidocaine into the abdominal wall can ease chronic pain caused by a trapped nerve. About 45 adults with this condition will receive the injection as part of their normal care and report their pain levels over three months. Researchers will al…

This study looks at how a drug that blocks a natural hormone (GnRH) affects cervical mucus at four points during the menstrual cycle. Fifteen healthy women with regular cycles will give blood, mucus, tissue, and vaginal swab samples. The goal is to understand mucus changes at the…

This study looks at different types of iris tumors using a special imaging technique called OCT angiography. Researchers will compare images from healthy eyes and eyes with tumors to see if this method can better tell benign from malignant growths. About 100 participants will joi…

This study looks at how eating a high-fat diet can change your body's internal clock, which controls sleep and other daily rhythms. Researchers will track 14 healthy, lean adults over 46 days, including 18 days spent in a research center. The goal is to understand how quickly the…

This study uses a special camera (OCT) to measure swelling in the clear front part of the eye (cornea) in people with Fuchs' dystrophy or a related condition. Researchers want to see if these measurements can predict how vision changes after surgery. About 60 adults with damaged …

This study tests whether a small vibrating device worn on the body can help people with Parkinson's disease walk more automatically and steadily. Sixty participants will be randomly assigned to receive either personalized vibrations timed to each step or fixed-interval vibrations…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have 'non-dipping' blood pressure that stays high overnight. The goal is to uncover mechanisms, n…

This study is observing 640 pregnant people to develop a tool that can predict placental insufficiency — a condition where the placenta doesn't work well and can lead to stillbirth or other serious problems. Participants are followed during pregnancy, and researchers will use the…

This study looks at whether special eye scans can find early signs of Alzheimer's disease and other dementias. Researchers will check for changes in blood flow and protein buildup in the retinas of 20 older adults with mild dementia, compared to healthy volunteers. The goal is to…

This study tests whether a special imaging technique (OCT) can help fit scleral contact lenses more accurately than the current standard method. About 258 people with conditions like keratoconus or previous eye surgery will have two lens fittings—one using the standard method and…

This study looks at how keeping a consistent sleep schedule affects heart health and metabolism in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will track sleep patterns and measure things like blood pressure, heart rate, and blood s…