Oregon Health And Science University

This study looks at whether people with a type of heart disease called obstructive hypertrophic cardiomyopathy can safely switch from one medication (mavacamten) to another (aficamten). The goal is to keep the heart working better and reduce symptoms. About 40 adults who are alre…

This study tests whether a sugar called L-fucose can improve movement and coordination in adults with GLUT1 deficiency syndrome, a rare genetic disorder that affects the brain's energy supply. Sixteen participants will receive either fucose or a placebo for a period, then switch,…

This study tests guselkumab (Tremfya), a drug already used for psoriasis, in 17 adults with pyoderma gangrenosum—a rare disease that leads to painful, hard-to-heal skin ulcers. Participants receive injections every 4 weeks for 28 weeks. Researchers will check if ulcers heal compl…

This study looks at whether adding addiction counseling and a community peer helper to regular primary care helps people with opioid use disorder stay on their medication (buprenorphine) and keep coming to their doctor visits. About 70 adults with opioid dependence and other medi…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsil and adenoid removal for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery …

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest can improve survival. About 585 adults with a shockable heart rhythm will be enrolled. The goal is to see if this change in timing helps restore a normal heartbeat f…

This study follows 300 teens and young adults (ages 10-24) with inherited bleeding disorders who choose either a levonorgestrel IUD or norethindrone acetate pills for heavy menstrual bleeding. Researchers will track bleeding patterns, satisfaction, and quality of life over six mo…

This study compares a personalized surgical approach using sleep endoscopy to standard tonsil removal in 240 children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. The goal is to see if tailoring surgery to each child's specific airway blockages imp…

This study tests a laser-guided procedure to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The procedure uses OCT scans to plan a custom laser treatment that smooths the cornea and strengthens it with cross-linking. Researchers aim to se…

This study tests a radioactive imaging agent called Iodine-124 evuzumitide (AT-01) in 150 people with systemic amyloidosis. The goal is to see how well it detects amyloid deposits in the heart and other organs using PET/MRI or PET/CT scans. If accurate, it could become a new tool…

This study aims to improve how doctors detect, classify, and treat irregular corneas caused by conditions like keratoconus, dry eye, and corneal scars. Researchers will use a special imaging device called optical coherence tomography (OCT) to get detailed measurements of the corn…

This study tests whether a 4-week virtual balance training program, guided by a physical therapist and monitored with wearable sensors, can improve balance and reduce fall risk in older adults with Parkinson's disease. Eighty participants aged 55-85 will complete 12 remote sessio…

This study tests a simple sleep intervention for children ages 3-7 who resist going to bed. The approach includes a 'Bedtime Pass' that kids can trade for one trip out of the bedroom, plus basic sleep tips. Researchers want to see if pediatricians can deliver this during regular …

This study tests a wearable device that provides gentle vibrations timed to each step, aiming to make walking more automatic for people with Parkinson's disease. Sixty participants will be randomly assigned to receive either personalized step-synchronized cues or fixed-interval c…

This study tests a newer type of deep brain stimulation (DBS) that aims to control essential tremor while causing fewer problems with speech, walking, and balance. About 24 adults with hand tremors for at least 3 years will receive both directional and standard DBS to compare whi…

This study tests a video-based program called STELLA-FTD that helps family members caring for a loved one with frontotemporal dementia (FTD). The program teaches caregivers how to manage difficult behaviors and connect with community resources. Researchers will enroll 640 caregiv…

This study tests an 8-week online program called STELLA-R that teaches dementia caregivers a simple ABC method to understand and respond to upsetting behaviors. About 238 caregivers in Oregon, Washington, and Idaho will try the program and report how it affects their stress and r…

Morton's neuroma causes burning or shooting pain in the ball of the foot, often in middle-aged women. This study compares freezing the nerve (cryoablation) plus a steroid/lidocaine injection against the injection alone. 32 adults who haven't improved with orthotics or pads will b…

This study tests whether women living in rural areas can use a simple TENS device at home to reduce overactive bladder symptoms. Thirty-eight women will apply mild electrical stimulation to a nerve in their ankle for 30 minutes, three times a week for 12 weeks. Researchers will t…

This study tests whether wearable sensors that give real-time feedback during physical therapy can help people with mild traumatic brain injury recover balance and movement better than standard therapy. About 100 adults aged 18-60 who are still having symptoms 2 weeks to 6 months…

This study compares a home pelvic floor physical therapy program to standard care for 30 women having endometriosis surgery (without hysterectomy). Participants will report their pain and quality of life over the recovery period. The goal is to see if a simple home program can ea…

This study tests whether injecting lidocaine into the abdominal wall can reduce chronic pain caused by trapped nerves. Researchers will follow 45 adults for three months, measuring pain levels and any side effects. The goal is to see if this simple procedure can provide lasting r…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have a 'non-dipping' pattern where blood pressure stays high at night. The goal is to uncover mec…

This study looks at how a hormone-blocking drug called Relugolix affects cervical mucus in healthy women. Fifteen participants will take the drug for 10 days, and researchers will collect samples of blood, mucus, and tissue at different times. The goal is to better understand how…

This study is gathering information from 640 pregnant people to build a computer model that can predict placental insufficiency — a condition where the placenta doesn't work well and can lead to stillbirth. Participants will have extra ultrasounds and blood tests during pregnancy…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study looks at how eating a high-fat diet can change your body's internal clock, which controls sleep and other daily rhythms. Researchers will track 14 healthy, lean adults over 46 days, including 18 days spent in a research center. The goal is to understand how quickly the…

This study is testing whether special eye scans can detect signs of Alzheimer's disease and dementia. Researchers will use two non-invasive imaging devices to look for blood vessel changes and protein deposits in the retina. The study involves 20 participants, including people wi…

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …

This study uses a special eye scan called OCT angiography to look at iris tumors in 100 people. Researchers want to see if this scan can tell the difference between harmless and cancerous growths better than current methods. Participants include people with iris tumors and health…

This study uses a special eye scan called OCT to measure swelling in the cornea of people with Fuchs' dystrophy or a related condition. Researchers want to see if this scan can predict how vision changes after surgery. About 60 participants will be observed over time.