Hormonal showdown: which treatment tames heavy periods in bleeding disorders?

NCT ID NCT05916469

Recruiting now Disease control Sponsor: Oregon Health and Science University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 300 teens and young adults (ages 10-24) with inherited bleeding disorders who choose either a levonorgestrel IUD or norethindrone acetate pills for heavy menstrual bleeding. Researchers will track bleeding patterns, satisfaction, and quality of life over six months to see which option works better. The goal is to provide clear guidance on managing heavy periods in this population.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Levonorgestrel intrauterine system (LNG-IUD) and norethindrone acetate (NETA)
What this could lead to: If this study succeeds, it could help doctors choose the best hormonal treatment for heavy menstrual bleeding in young people with bleeding disorders, improving their quality of life.
What could go wrong: This is an observational study, not a randomized trial, so results may be less definitive. The study is also relatively small and focused on a specific age group, so findings may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

hemorrhagic disease hereditary von Willebrand disease Menorrhagia vascular hemostatic disease von Willebrand disease (hereditary or acquired)

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLEEDING DISORDER HEAVY MENSTRUAL BLEEDING VON WILLEBRAND DISEASES

Contacts and locations

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Locations

Children's Mercy
NOT_YET_RECRUITING

Kansas City, Missouri, 64108, United States
Colorado Anschutz Medical Campus
NOT_YET_RECRUITING

Aurora, Colorado, 80045, United States
Emory
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Penn State Health
NOT_YET_RECRUITING

Hershey, Pennsylvania, 17003, United States
Seattle Children's Hospital
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
Stanford
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
University of Michigan Medicine
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Washington
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States

Contact Email: •••••@•••••

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