Could an epinephrine shot prevent pancreatitis after ERCP?

NCT ID NCT07173179

Completed Disease control Sponsor: Duzce University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal was to see if the combination worked better than the anti-inflammatory drug alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: epinephrine injection and rectal indomethacin
What this could lead to: If it works, this could offer a simple, low-cost way to lower the risk of pancreatitis after a common bile duct procedure.
What could go wrong: This is a completed Phase 4 trial, but the results are not yet published. The added benefit of epinephrine injection over standard care may be small, and injection carries a slight risk of bleeding or tissue damage.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis cholestasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-ERCP ACUTE PANCREATITIS

Contacts and locations

Locations

Duzce University School of Medicine

Düzce, 81620, Turkey (Türkiye)

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