Could an arthritis drug tame pancreatitis inflammation?

NCT ID NCT03684278

Recruiting now Disease control Sponsor: University of Liverpool Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests whether a single infusion of infliximab, a drug used for arthritis and Crohn's disease, can reduce inflammation in adults with acute pancreatitis. About 290 participants will receive either a low dose, a high dose, or a placebo. The main goal is to see if infliximab lowers C-reactive protein levels, a marker of inflammation, over two weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Infliximab (Remicade), an anti-inflammatory drug given as a single infusion
What this could lead to: If it works, this could point toward a new treatment to reduce severe inflammation in acute pancreatitis, potentially preventing complications.
What could go wrong: This is a mid-stage trial with only 290 people, so results may not apply to everyone. Infliximab can increase infection risk, and it's being tested for a new use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PANCREATITIS

Contacts and locations

Locations

Aberdeen Royal Infirmary
RECRUITING

Aberdeen, Aberdeenshire, AB25 2ZN, United Kingdom
Aintree University Hospital
RECRUITING

Liverpool, Merseyside, L9 7AL, United Kingdom
Arrowe Park Hospital
WITHDRAWN

Upton, Wirral, CH49 5PE, United Kingdom
Charing Cross Hospital
TERMINATED

London, Greater London, W6 8RF, United Kingdom
John Radcliffe Hospital
RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Queen's Medical Centre
TERMINATED

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom
Royal Cornwall Hospital
WITHDRAWN

Truro, Cornwall, TR1 3LJ, United Kingdom
Royal Devon and Exeter Hospital
RECRUITING

Exeter, Devon, EX2 5DW, United Kingdom
Royal Liverpool University Hospital
RECRUITING

Liverpool, Merseyside, L7 8XP, United Kingdom
St James's University Hospital
RECRUITING

Leeds, West Yorkshire, LS9 7TF, United Kingdom
St Mary's Hospital
TERMINATED

London, Greater London, W2 1NY, United Kingdom
University College London Hospital
RECRUITING

London, Greater London, NW1 2BU, United Kingdom
University Hospital of Wales
RECRUITING

Cardiff, Cardiff, CF14 4XW, United Kingdom
Whiston Hospital
TERMINATED

Whiston, Merseyside, L35 5DR, United Kingdom

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