New combo approach aims to stop pancreatitis after stone treatment

NCT ID NCT07202559

Recruiting now Prevention Sponsor: Changhai Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving extra IV fluids along with a standard anti-inflammatory suppository can better prevent pancreatitis after a procedure to break up pancreatic stones. About 1250 adults with chronic pancreatitis will be randomly assigned to receive either the combination or the suppository alone. The main goal is to see if the combination reduces the number of people who develop pancreatitis after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactated Ringer's solution and indometacin suppository
What this could lead to: If it works, this could become a standard way to prevent pancreatitis after pancreatic stone treatment, reducing serious complications.
What could go wrong: This is an early-stage trial without a phase designation, so results are uncertain. Adding IV fluids may not improve outcomes and could cause fluid overload in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis chronic pancreatitis pancreatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC DUCT STONES PANCREATITIS, ACUTE PANCREATITIS, CHRONIC

Contacts and locations

Locations

Changhai Hospital
RECRUITING

Shanghai, China
Hangzhou First People's Hospital
RECRUITING

Hangzhou, China
Peking Union Medical College Hospital
RECRUITING

Beijing, China
Qilu Hospital of Shandong University
RECRUITING

Shandong, China
Ruijin Hospital
RECRUITING

Shanghai, China
Shanghai Pudong New Area Gongli Hospital
RECRUITING

Shanghai, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, China
The Second Affiliated Hospital of Baotou Medical College
RECRUITING

Baotou, China
The Third Xiangya Hospital of Central South University
RECRUITING

Hunan, China
Yunnan University Affiliated Hospital
NOT_YET_RECRUITING

Yunnan, China

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