Could a Half-Dose of a common drug prevent a painful complication just as well?
NCT ID NCT07088757
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a low dose (50 mg) versus the standard dose (100 mg) of indomethacin given rectally before ERCP to prevent post-procedure pancreatitis. About 1,366 adults undergoing ERCP will be randomly assigned to one of the two doses in a double-blind fashion. The goal is to see if the lower dose works just as well while potentially causing fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- indomethacin (a nonsteroidal anti-inflammatory drug given as a rectal suppository)
- What this could lead to
- If successful, a lower dose could prevent post-ERCP pancreatitis just as effectively as the standard dose, while reducing side effects like bleeding or kidney problems.
- What could go wrong
- This is a non-inferiority trial, so the lower dose might prove slightly less effective. The study is also limited to adults in China, so results may not apply everywhere.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Hospital of Jiaxing University
NOT_YET_RECRUITINGZhejiang, China
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Changhai Hospital
NOT_YET_RECRUITINGShanghai, China
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Dongyang People's Hospital
NOT_YET_RECRUITINGZhejiang, China
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First Affiliated Hospital of Ningbo University
NOT_YET_RECRUITINGZhejiang, China
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Jinhua Central Hospital
NOT_YET_RECRUITINGZhejiang, China
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People's Hospital of Quzhou
NOT_YET_RECRUITINGZhejiang, China
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Ruijin Hospital
RECRUITINGShanghai, China
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Shanghai General Hospital
NOT_YET_RECRUITINGShanghai, China
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Shaoxing People's Hospital
NOT_YET_RECRUITINGZhejiang, China
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Sir Run Run Shaw Hospital
RECRUITINGZhejiang, China
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Taizhou Enze Medical Center Group
RECRUITINGZhejiang, China
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Zhuji People's Hospital of Zhejiang Province
NOT_YET_RECRUITINGZhejiang, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a simple ice water flush prevent pancreatitis after a common procedure?
- Common painkiller may prevent pancreatitis after bile duct procedure
- Can a simple pill prevent pancreatitis after ERCP? new study tests two drugs
- When to remove pancreatic stents? new trial aims to find out
- Can a double dose stop Post-Procedure pancreatitis?