Could a simple pill prevent a painful complication after endoscopy?

NCT ID NCT05252754

Recruiting now Prevention Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding an oral medication (tacrolimus) before an ERCP procedure can prevent pancreatitis, a painful inflammation of the pancreas that sometimes occurs afterward. About 4,800 adults undergoing ERCP will be randomly assigned to receive either the standard rectal medication alone or the standard medication plus oral tacrolimus. The goal is to see if the combination reduces the number of people who develop pancreatitis after the procedure.

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Conditions

The condition(s) this trial relates to.

acute pancreatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-ERCP ACUTE PANCREATITIS

Contacts and locations

Locations

Apollo Multispecialty Hospitals,
NOT_YET_RECRUITING

Kolkata, West Bengal, 700054, India
Asian Institute of Gastroenterology
RECRUITING

Hyderabad, Andhra Pradesh, 500082, India
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Post Graduate Institute of Medical Education and Research
NOT_YET_RECRUITING

Chandigarh, 160012, India
Singapore General Hospital
NOT_YET_RECRUITING

Singapore, 169608, Singapore

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