New shot every 3 months could stop pancreatitis in people with Sky-High triglycerides

NCT ID NCT06880770

Recruiting now Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can prevent future pancreatitis episodes and lower triglyceride levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

plozasiran (a drug injection given every three months)

What this could lead to

If it works, this could offer a new way to lower dangerously high fat levels in the blood and reduce the risk of painful pancreatitis attacks.

What could go wrong

This is still a clinical trial, so it is not yet proven to work. The study is relatively small (288 people) and results may not apply to everyone. Possible side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia acute pancreatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE HYPERTRIGLYCERIDEMIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Clinical Research Site 1
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Mesquite, Texas, 75149, United States
Clinical Research Site 2
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San Antonio, Texas, 78233, United States
Clinical Research Site 3
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Greensboro, North Carolina, 27401, United States
Clinical Research Site 4
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Santa Clarita, California, 91321, United States
Clinical Research Site 5
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North Platte, Nebraska, 69101, United States
Clinical Research Site 6
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Springfield, Illinois, 62702, United States
Clinical Research Site 7
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Philadelphia, Pennsylvania, 19107, United States
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Plovdiv, 4002, Bulgaria
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Beijing, Beijing Municipality, 100730, China
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Baotou, Inner Mongolia, 014010, China
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Nanchang, Jiangxi, 330006, China
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Shanghai, Shanghai Municipality, 201620, China
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Hangzhou, Zhejiang, 310000, China
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Amman, 11821, Jordan
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Irbid, 21166, Jordan
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Irbid, 22110, Jordan
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Belgrade, 11000, Serbia
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Zaječar, 19000, Serbia
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Gothenburg, 41345, Sweden
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Stockholm, 14186, Sweden
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Los Angeles, California, 90027, United States
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New Haven, Connecticut, 06519, United States
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Indianapolis, Indiana, 46202, United States
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Kansas City, Kansas, 66160, United States
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Ann Arbor, Michigan, 48109, United States
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St Louis, Missouri, 63110, United States
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Wilmington, North Carolina, 28412, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Seattle, Washington, 98109, United States
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Ramos Mejía, Buenos Aires, 1704, Argentina
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Córdoba, Córdoba Province, 5000, Argentina
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Córdoba, Córdoba Province, X5003DCE, Argentina
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Rosario, Santa Fe Province, 2000, Argentina
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Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
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Graz, 8036, Austria
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Linz, 4021, Austria
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Vienna, 1130, Austria
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Fortaleza, Ceará, 60430-370, Brazil
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Belo Horizonte, Minas Gerais, 30150-274, Brazil
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Belo Horizonte, Minas Gerais, 30150-320, Brazil
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Belo Horizonte, Minas Gerais, 30220-140, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Pôrto Alegre, Rio Grande do Sul, 90050-170, Brazil
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São Paulo, São Paulo, 05403-900, Brazil
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São Paulo, São Paulo, 99999, Brazil
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Burgas, 8000, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4003, Bulgaria
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Rousse, 7013, Bulgaria
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Sofia, 1404, Bulgaria
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Sofia, 1431, Bulgaria
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Stara Zagora, 6000, Bulgaria
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Guiyang, Guizhou, 550000, China
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Harbin, Heilongjiang, 150040, China
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Luoyang, Henan, 471000, China
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Zhuzhou, Hunan, 412000, China
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Chifeng, Inner Mongolia, 024099, China
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Chengdu, Sichuan, 610041, China
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Hangzhou, Zhejiang, 310003, China
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Wenzhou, Zhejiang, 325000, China
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Beijing, 100053, China
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Changsha, 410015, China
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Chengdu, 610074, China
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Nanjing, 210002, China
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Barranquilla, 080020, Colombia
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Bogotá, 111211, Colombia
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Bogotá, 111411, Colombia
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Cali, 760042, Colombia
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Puerto Colombia, 081007, Colombia
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Budapest, 1083, Hungary
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Budapest, 1132, Hungary
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Pécs, 7624, Hungary
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Szeged, 6725, Hungary
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Amman, 11190, Jordan
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Amman, 11942, Jordan
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Guadalajara, Jalisco, 44670, Mexico
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Mexico City, Mexico City, 06700, Mexico
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Muscat, 123, Oman
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Riyadh, 11211, Saudi Arabia
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Riyadh, 11426, Saudi Arabia
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Riyadh, 11472, Saudi Arabia
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Belgrade, 11000, Serbia
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Pančevo, 26000, Serbia
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Singapore, 768828, Singapore
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Seongnam-si, Gyeonggi-do, 13620, South Korea
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Jeonju, Jeollabuk-do, 54907, South Korea
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Busan, 49201, South Korea
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Sejong, 30099, South Korea
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Seoul, 02841, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Abu Dhabi, 133500, United Arab Emirates
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Abu Dhabi, 51900, United Arab Emirates
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Al Ain City, 15258, United Arab Emirates