Which NSAID is best? large trial tests indomethacin vs diclofenac to prevent Post-ERCP pancreatitis

NCT ID NCT07071441

Recruiting now Prevention Sponsor: Air Force Military Medical University, China Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two rectal non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and diclofenac, to see which one better prevents pancreatitis after an ERCP procedure. About 4050 adults aged 18-90 with an intact papilla will be randomly assigned to receive one of the drugs before the procedure. The goal is to find out if indomethacin is superior to diclofenac in reducing the risk of this common complication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indomethacin and diclofenac (non-steroidal anti-inflammatory drugs, given as rectal suppositories)
What this could lead to: If it works, this could show that indomethacin is better than diclofenac at preventing pancreatitis after ERCP, helping doctors choose the most effective preventive drug.
What could go wrong: This is a large trial, but it follows an earlier smaller study that was stopped early. The difference between the two drugs may still be small, and individual patient factors could affect results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pancreatitis acute pancreatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DICLOFENAC ERCP INDOMETHACIN NON-STEROIDAL ANTI-INFLAMMATORY (NSAID) PANCREATITIS

Contacts and locations

Locations

986 Hospital of Xijing Hospital
RECRUITING

Xi'an, Shaanxi, 710000, China
Affiliated Hangzhou First People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310000, China
Department of Gastroenterology, Hongai Hospital
RECRUITING

Xiamen, Fujian, 361000, China
Eastern Hepatobiliary Surgery Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Harbin Medical University Affiliated Fourth Hospital
RECRUITING

Harbin, Heilongjiang, 150000, China
Huaihe Hospital of Henan University
RECRUITING

Kaifeng, Hennan, 475000, China
Jilin Miniciple People'S Hospital
RECRUITING

Jilin City, Jilin, 132000, China
Qinghai University Affiliated Hospital
RECRUITING

Xining, Qinghai, 810000, China
Renmin hospital of Wuhan University
RECRUITING

Wuhan, Hubei, 430000, China
Second Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710000, China
Shandong Provincial Third Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250000, China
The 960th Hospital of the PLA
RECRUITING

Jinan, Shandong, 250000, China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 404100, China
The Third Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410000, China
The first medical center, Chinese PLA General Hospital
RECRUITING

Beijing, Beijing Municipality, 100000, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430000, China
Xijing Hospital of Digestive Diseases
RECRUITING

Xi'an, Shaanxi, 710000, China
[email protected]
RECRUITING

Harbin, Heilongjiang, 150000, China
the First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310000, China
the second Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310000, China

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