CHRONIC PANCREATITIS

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study is testing a new scoring system called OC26 to help doctors more accurately diagnose autoimmune pancreatitis, a condition where the immune system attacks the pancreas. Researchers will review medical data from 82 adults suspected of having the disease. If the OC26 crit…

This study aims to develop a non-invasive breath test to detect pancreatic cancer earlier. Pancreatic cancer is often diagnosed late because early symptoms are vague. The test measures tiny molecules in breath that may signal cancer. Researchers will collect breath and urine samp…

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

This study tests an artificial intelligence (AI) system that analyzes contrast-enhanced CT scans to help diagnose and manage pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitoring, or routine follow-up. Researchers will…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice beverage every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. The goal is to see if the drin…

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to check if the drug is feasible and acceptable. The goal is to see if it helps…

This study tracks how well a nerve block procedure called celiac plexus neurolysis (CPN) helps manage pain in people with chronic pancreatitis. Researchers will follow 35 patients for 24 weeks, recording their pain scores and pain medication use. The goal is to see if the procedu…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis who suffer from severe abdominal pain. The program uses psychological techniques to help reduce pain's impact on daily life and improve quality of life. Researchers aim to enr…

This early-phase trial tests whether paricalcitol, a vitamin D analog, can improve quality of life in adults with chronic pancreatitis. Researchers will enroll 24 participants to take either the drug or a placebo for 12 months. The main goal is to see if the study is feasible and…

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study aims to collect and analyze pancreatic fluid from 24 healthy adults after giving them a synthetic hormone called secretin. The secretin is injected during an endoscopic ultrasound to stimulate the pancreas to release fluid, which is then collected from the duodenum. Re…

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study collects blood, tissue, and health information from 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or cysts. The goal is to create a large database and sample bank that researchers can use to better understand these conditions and develop be…

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study is following 1,250 people at higher risk for pancreas cancer, including those with new diabetes, pancreatic cysts, or a family history. Researchers will collect blood samples and health data twice a year for several years. The goal is to find early markers in the blood…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study is looking for ways to predict which people with chronic pancreatitis will get pain relief from a procedure called endoscopic therapy. Researchers will use brain scans, nerve tests, and questionnaires before the procedure, then track pain levels for up to 18 months. Th…

This study looks at blood markers and how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed and get their own islets back. Researchers will follow 100 adults for at least two years to understand graft function…

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study aims to collect medical history, family history, and blood or urine samples from 10,000 people with or at risk for pancreatic cancer. Researchers will use this information to look for genetic and environmental factors linked to the disease. Participants may also be ask…