CHRONIC PANCREATITIS

This study tests whether adding a patient's own stem cells to an islet transplant can improve insulin production and reduce diabetes after pancreas removal for chronic pancreatitis. About 42 adults will be randomly assigned to receive either stem cells plus islets or islets alone…

This study is testing whether a mixed meal test can accurately diagnose type 3c diabetes, a form of diabetes that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 85 who have one of these conditions. The goal is to imp…

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best next step for people with suspected pancreatic diseases. The AI will classify patients into three groups: immediate treatment, close monitoring, or routine …

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis. The goal is to reduce pain severity and its interference with daily activities like sleep, mood, and work. Researchers will enroll 280 participants to see if this psychologic…

This pilot study is testing whether simvastatin, a widely used cholesterol medication, can improve quality of life for adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to see if the drug is practical and well-tolerated, and whether it h…

This early-stage study tests if stem cells taken from a patient's own bone marrow can reduce pain and improve pancreas function in people with chronic pancreatitis. About 40 adults with long-term pain will receive the treatment and be monitored for changes in pain scores, medicat…

This study tests Scrambler Therapy, a non-invasive device that sends gentle electrical signals through the skin to retrain how the brain feels pain. It is for adults with chronic pancreatitis whose belly pain has not improved with standard treatments. About 40 participants will r…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. Everyone in the trial gets the same dri…

This study is testing a procedure called EUS-CPN, which uses an ultrasound to guide a nerve block for people with long-term pancreatitis pain. Researchers will track pain levels and painkiller use for 24 weeks after the procedure. The goal is to see if this treatment helps reduce…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with long-term abdominal pain from chronic pancreatitis. About 24 adults will take the drug for 7 days and be monitored for side effects and p…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will measure pain changes, opioid use, and quality of life in 48 adults over 6 months. The goal is to see if this approach is safe and offers rel…

This early-stage study tests whether paricalcitol, a vitamin D-like drug, can improve quality of life in 24 adults with chronic pancreatitis. Participants take the drug or a placebo for 12 months while reporting pain and overall health. The goal is to see if the treatment is prac…

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study uses a special blood test to find mild to moderate pancreas problems in people with chronic or recurrent pancreatitis. Some participants will then receive either pancreatic enzyme replacement therapy or a placebo for 8 weeks to see if it improves their quality of life.…

This study collects medical information, blood, tissue, and other samples from up to 20,000 people with pancreas diseases like pancreatic cancer or pancreatitis. The goal is to build a resource that helps researchers better understand these conditions and develop better screening…

This study follows 1250 people at higher risk for pancreas cancer—such as those with new diabetes, pancreas cysts, or a family history—to find early warning signs in the blood. Participants visit Omaha twice a year to give blood samples. The goal is to develop a screening test th…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict which patients with chronic pancreatitis will get pain relief from procedures like endoscopy or surgery. About 150 adults with chronic pancreatitis will take the tes…

This study collects blood, saliva, urine, or stool samples from up to 1,600 children with pancreatitis to look for genetic markers that might increase the risk of pancreatic cancer later in life. The goal is to better understand which children are at higher risk and why. Particip…

This study uses a technique called Quantitative Sensory Testing (QST) to understand pain patterns in people with chronic pancreatitis. Researchers will test 500 participants to see if these pain patterns can predict who will benefit from certain treatments. The goal is to make tr…

This study is a registry that follows 510 adults who receive therapeutic endoscopic ultrasound (T-EUS) for conditions like blocked bile ducts, pancreatic fluid collections, or stomach blockages. Researchers will track how well these procedures work and any complications, comparin…

This study looks at how well insulin-producing cells (islets) work after being transplanted back into people with chronic pancreatitis who had their pancreas removed. Researchers will collect blood samples to measure inflammation and graft function. The goal is to understand what…

This study aims to collect and analyze pancreatic fluid from healthy volunteers after they receive an injection of human secretin. Researchers will measure the levels of bicarbonate, sodium, potassium, and chloride in the fluid. The goal is to understand normal pancreatic fluid c…

This study looks at whether brain activity and pain sensitivity tests can predict how well someone with chronic pancreatitis will respond to endoscopic therapy. About 100 adults scheduled for the procedure will have EEGs, sensory tests, and questionnaires before treatment. Their …