OPIOID DEPENDENCE

This early study is testing two new long-acting injection versions of a medication called naltrexone, which is used to help manage opioid and alcohol dependence. The study will involve 40 healthy male volunteers to see how the body processes these new injections compared to the e…

This study aims to help cancer survivors who have chronic pain reduce their long-term opioid use safely. It will test four different treatment approaches, including specialized pain care and medication changes, to see which works best. The goal is to lower opioid doses by at leas…

This study is testing whether adding counseling and a community peer navigator to standard medication treatment helps people with opioid addiction and other health problems stay in treatment and engage more with their primary care. Researchers will compare this enhanced 'MOUD Plu…

This small, early-stage study is testing whether therapy sessions guided by the psychedelic compound psilocybin can help people with chronic pain safely reduce or stop their opioid pain medication. The study will involve 10 adults who have previously struggled to taper off opioid…

This study tests a community program that helps young people with opioid addiction get treatment faster. The program sends outreach teams to connect youth with medication, counseling, and peer support right away. Researchers want to see if this approach helps young people stay in…

This early-stage study is testing whether adding an existing epilepsy drug, lacosamide, to standard opioid painkillers is safe and tolerable for adults with chronic pancreatitis. The main goal is to see if the combination helps reduce severe abdominal pain and might allow patient…

This study aims to understand why some people relapse after starting medication treatment for opioid addiction. Researchers will use brain scans on 240 people recently starting treatment to look for patterns linked to staying drug-free. The goal is to learn how the brain changes …