New pill could ease Post-Surgery pain without opioids

NCT ID NCT06215820

Completed Symptom relief Sponsor: Viatris Specialty LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called MR-107A-02 for treating acute pain after bunionectomy (foot surgery). 410 adults received either the new drug, a placebo, or tramadol (a standard painkiller). The main goal was to see if MR-107A-02 provides better pain relief than placebo, measured by pain scores over time. The trial also tracked how many patients needed extra opioid pain medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MR-107A-02 (a tablet for pain relief)
What this could lead to: If it works, this could offer a new option for managing acute pain after foot surgery, potentially reducing the need for opioid rescue medication.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not prove more effective than existing painkillers, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN PAIN POST-OPERATIVE PAIN

Contacts and locations

Locations

Investigator site 101

Salt Lake City, Utah, 84107, United States
Investigator site 102

Pasadena, Maryland, 21122, United States
Investigator site 103

Anaheim, California, 92801, United States
Investigator site 104

O'Fallon, Illinois, 62269, United States
Investigator site 105

San Antonio, Texas, 62269, United States
Investigator site 106

Houston, Texas, 77008, United States
Investigator site 107

Carrollton, Texas, 75007, United States
Investigator site 108

Tampa, Florida, 33613, United States
Investigator site 109

Atlanta, Georgia, 30331, United States
Investigator site 110

Riverside, California, 92501, United States
Investigator site 111

McAllen, Texas, 78501, United States
Investigator site 112

Miami, Florida, 35660, United States
Investigator site 113

Bellaire, Texas, 77401, United States
Investigator site 114

Sheffield, Alabama, 35660, United States
Investigator site 115

Phoenix, Arizona, 85053, United States

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