ACUTE PAIN

This study tests if watching relaxing virtual reality (VR) scenes before egg retrieval can lower pain. About 100 women having elective egg freezing will either get routine care or routine care plus a VR relaxation session. Pain levels are measured with standard pain scales before…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study compares two ways of deciding when to give extra pain medicine after surgery. One method uses a standard pain scale, while the other also considers how much pain limits movement. The goal is to see if the new method reduces unnecessary painkiller use. About 76 adults h…

This study tests two different numbing techniques to manage pain after heart surgery. 50 adults having open-heart surgery will receive either one nerve block or a combination of two others. The goal is to find which method provides better pain relief and reduces the need for stro…

This study compares two types of nerve blocks for pain after inguinal hernia surgery. One is a newer technique called the anterior iliac block, and the other is a standard ilioinguinal/iliohypogastric block. The goal is to see which provides longer pain relief and higher patient …

This study compares two methods of giving a pain-relieving shot (TAP block) after a planned C-section: one guided by ultrasound and one done by the surgeon during the operation. Fifty women will take part to see which method works better and faster for controlling pain after surg…

This study looks at whether a special numbing injection called the Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after surgery will receive either the Twin Block or a placebo…

This pilot study tests whether a special numbing injection called the Temporo-masseteric Nerve Block can reduce pain after wisdom tooth removal. About 20 adults will receive the injection during sedation and then report their pain levels and painkiller use for one week. The goal …

This study tests whether using a virtual reality headset can help reduce pain for adults with sickle cell disease who are in the emergency room for a painful crisis. About 30 participants will receive either standard care alone or standard care plus a VR experience. The goal is t…

This study looks at whether a rectus sheath block, a type of nerve block, can improve breathing and reduce pain after major upper abdominal surgery. About 60 adults having planned surgery with a midline cut will be included. Researchers will measure diaphragm movement and pain sc…

This study tests whether a special laser treatment (LightForce) can reduce pain from mild to moderate ankle sprains better than a fake laser. About 108 adults with ankle pain for less than 72 hours will receive either real or sham laser therapy, plus standard care like rest, ice,…

This study tests a single dose of an experimental painkiller (LY4515100) in 212 people who have moderate-to-severe pain after having their wisdom teeth removed. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will measure pain level…

This study tests two different nerve block techniques to manage pain after lumbar spine surgery. Sixty adults having single-level back surgery will receive either a standard or a modified block. The goal is to see which method reduces the need for opioid painkillers and improves …

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study looks at whether a single session of low-level laser therapy can quickly change how much pain a person feels and can tolerate. Researchers will compare the laser to a fake (sham) treatment in 52 healthy adults aged 18 to 35. The goal is to see if this safe, noninvasive…

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study compares two types of nerve blocks to control pain after single-level lumbar disc surgery. About 70 adults aged 18-70 will receive either a classic thoracolumbar block or a newer Quadro-iliac block. The goal is to see which method reduces the need for opioid painkiller…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having uppe…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study is testing a non-invasive device that measures pain by tracking changes in pupil size after gentle electrical stimulation. Researchers will enroll 100 children and teens aged 6 to 21 who are having surgery or a bone marrow transplant. The goal is to see if this device …

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve activity before and after heat …

This study works to create better tools for measuring acute pain in infants and young children (0 to under 2 years old). Researchers will interview 60 caregivers and clinicians to see if new pain assessment questions are clear, complete, and relevant. The goal is to develop relia…

This study aims to understand if severe, short-term pain experienced right before emergency surgery increases the risk of developing long-lasting chronic pain after the operation. Researchers will follow 693 adults in France who need urgent orthopedic or abdominal surgery. The go…