ACUTE PAIN

This study looks at whether giving magnesium sulfate through an IV can help manage pain and reduce the need for strong painkillers in trauma patients in the intensive care unit (ICU). About 156 adults with injuries will receive either magnesium or a saltwater solution. The goal i…

This study looks at whether a single session of low-level laser therapy can quickly change how much pain a person feels and can tolerate. Researchers will compare the laser to a fake (sham) treatment in 52 healthy adults aged 18 to 35. The goal is to see if this safe, noninvasive…

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This study tests if listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults with pain will be randomly assigned to hear either a mindfulness practice or standard injury advice. The goal is to see if a simple, no-drug ap…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study compares two types of nerve blocks to manage pain after heart surgery. About 50 adults having planned heart surgery will be randomly assigned to receive either an Erector Spinae Plane Block or a combination of two other blocks. The goal is to see which method provides …

This study tests whether watching relaxing virtual reality (VR) scenes before an egg retrieval procedure can help reduce pain. One hundred women will be randomly assigned to either standard care or standard care plus a VR relaxation session. Pain levels are measured with simple q…

This study looks at whether a rectus sheath block—a type of nerve block—can improve breathing and reduce pain after major upper abdominal surgery. Researchers will measure diaphragm movement and pain levels in 60 adults. The goal is to find a better way to manage recovery after s…

This study tests a special numbing injection (temporo-masseteric nerve block) to see if it lowers pain after wisdom tooth removal. About 20 adults will have the injection during sedation and then report their pain and painkiller use for a week. The goal is to find a better way to…

This study compares two types of nerve blocks used to control pain after inguinal hernia surgery. One is a newer method called the anterior iliac block, and the other is a standard ilioinguinal/iliohypogastric block. Researchers want to see which one provides longer pain relief a…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra pain medicine after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medicine based on either a stand…

This study tests whether using a virtual reality headset, along with usual pain medicine, can help adults with sickle cell disease feel better during a painful crisis. About 30 people in the emergency room will be split into groups to compare pain levels and comfort. The goal is …

This study looks at whether a special numbing injection called the Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain one day after surgery will receive either the Twin Block or a placebo…

This study tests two different nerve blocks to see which one works better for pain after lumbar spine surgery. About 60 adults having single-level back surgery will receive either a standard or a modified block. The goal is to reduce the need for strong painkillers and improve co…

This study tests whether adding a special laser treatment (called photobiomodulation) to standard care (rest, ice, compression, elevation, and exercise) reduces pain from a mild to moderate ankle sprain better than a fake laser plus standard care. About 108 adults with ankle pain…

This study looks at two methods of giving a pain-relieving shot (TAP block) after a planned C-section. One method uses ultrasound to guide the needle, the other is done by the surgeon during the operation. The goal is to see which approach works better and faster for controlling …

This study compares two types of nerve blocks to control pain after single-level lumbar disc surgery. About 70 adults aged 18-70 will receive either a classic thoracolumbar block or a newer Quadro-iliac block. The goal is to see which method reduces the need for opioid painkiller…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having uppe…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and then undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain bett…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes chronic, improves, or flares up. A smalle…

This study is testing a non-invasive device that measures pupil changes to objectively assess pain in children and teens aged 6 to 21. Participants are undergoing elective surgery or bone marrow transplant. The device does not change their treatment—it only collects data to help …

This study looks at whether oxytocin, a natural hormone, can change how nerves send pain signals after mild heat. Sixty healthy adults will receive either oxytocin or a placebo through an IV. Researchers will measure nerve activity and pain ratings when light and firm pressure is…

This study works to create better tools for measuring acute pain in infants and young children (0 to under 2 years old). Researchers will interview 60 caregivers and clinicians to see if new pain assessment questions are clear, complete, and relevant. The goal is to develop relia…

This study aims to understand if severe, short-term pain experienced right before emergency surgery increases the risk of developing long-lasting chronic pain after the operation. Researchers will follow 693 adults in France who need urgent orthopedic or abdominal surgery. The go…