ACUTE PAIN

This study tests whether a numbing injection called Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain the day after surgery will receive either the Twin Block or a placebo. Researchers w…

This study compares two ultrasound-guided nerve blocks—recto-intercostal fascial plane block (RIFPB) and transversus abdominis plane block (TAPB)—for pain control after laparoscopic gallbladder removal. 90 adults undergoing elective surgery will receive one of the two blocks. The…

This study compares three intravenous painkillers—fentanyl, tramadol, and ibuprofen—given through a patient-controlled pump after lung surgery. The goal is to see which one controls pain and helps patients breathe better in the first 72 hours after surgery. The trial will include…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This Phase 2 trial tests a single oral dose of LY4515100 against a placebo in 212 people with moderate-to-severe pain after having their wisdom teeth removed. The goal is to see if the drug safely reduces pain intensity and how quickly it works. Participants stay in a research un…

This study compares two types of nerve blocks for pain relief after inguinal hernia surgery: the standard ilioinguinal/iliohypogastric block and a newer anterior iliac block. Researchers want to see which provides longer pain relief and higher patient satisfaction. The trial will…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests if watching relaxing virtual reality (VR) scenes before an egg retrieval procedure can lower pain. One hundred women having elective egg freezing will either get standard care or standard care plus a VR relaxation session. Pain levels are measured with a simple 0…

This study compares two regional anesthesia techniques to manage pain in 50 adults undergoing heart surgery via a chest incision. One group receives an Erector Spinae Plane Block, while the other gets a combination of Superficial Parasternal Intercostal Plane Block and Serratus A…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 will take p…

This study looks at whether a single session of low-level laser therapy (LLLT) can immediately change how much pain a person can handle. Healthy adults aged 18-35 will receive either real or fake laser treatment, and their pain threshold and tolerance will be measured. The goal i…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests two different nerve block techniques to manage pain after lumbar spine surgery. Sixty adults undergoing single-level back surgery will receive either a standard or a modified block. The goal is to see which method reduces the need for opioid painkillers and impro…

This study tests two different nerve blocks to see which one works better for pain after single-level lumbar disc surgery. 70 adults will receive one of the blocks before surgery, and their pain and opioid use will be tracked for 24 hours. The goal is to find a more effective way…

This study tests two methods of delivering a TAP block—a type of pain shot—after a planned C-section. One method uses ultrasound to guide the needle, the other is done by the surgeon during the operation. The goal is to see which approach provides better pain control and is faste…

This study tests whether using virtual reality (VR) alongside standard care can reduce pain for adults with sickle cell disease who are in the emergency department with a painful crisis. About 30 participants will be split into three groups to compare pain scores and comfort. The…

This study tests whether a special numbing injection called a temporo-masseteric nerve block (TMNB) can reduce pain after wisdom tooth removal. About 20 adults having their lower wisdom teeth taken out under sedation will receive the injection and then report their pain levels an…

This study tests whether a continuous intravenous infusion of magnesium sulfate can reduce pain and the need for narcotic painkillers in critically ill trauma patients admitted to the intensive care unit. Researchers will compare magnesium to a placebo (normal saline) in 156 adul…

This study tests whether a device called LightForce® Therapy Laser can reduce pain from mild to moderate ankle sprains. About 108 adults with acute ankle sprain pain will receive either real laser therapy or a sham (fake) laser, plus standard care like rest and ice. The main goal…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study is testing whether a rectus sheath block, a numbing injection into the abdominal wall, can improve breathing and reduce pain in 60 adults undergoing major upper abdominal surgery. Participants will receive the block and be monitored for diaphragm movement and pain leve…

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This study looks at how a person's mental state—like anxiety, sleep problems, and fear of pain—affects how well numbing medication works during surgery. Researchers will follow 1,000 adults to see if these factors change pain levels, opioid use, and the chance of long-term pain. …

This study looks at whether oxytocin, a natural hormone, can change how nerves react to light touch and painful pressure after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve signals…

This study tests a new device that measures pain by looking at changes in pupil size after a gentle electrical stimulation. Researchers will enroll 100 children and teens ages 6 to 21 who are having surgery or bone marrow transplant. The device is non-invasive and does not change…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study involves interviews with 60 caregivers and clinicians to see how well they can describe and report acute pain in infants and young children under 2 years old. The goal is to create reliable tools for measuring pain in future clinical trials. The study does not test any…