ACUTE PAIN

This study tested whether genetic testing for two liver enzymes (CYP2D6 and CYP2C19) can help doctors prescribe better pain medicines after surgery. Over 1,600 participants were randomly assigned to either immediate genetic testing and tailored pain treatment or standard care. Th…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study tested whether coughing during a blood draw can reduce pain. Twenty-one healthy men had blood drawn twice—once with coughing and once without—and rated their pain. The goal was to understand how the 'cough-trick' works. If effective, it could offer a simple, drug-free …

This completed Phase 2 trial tested the drug VX-993 in 367 people who had bunion surgery. The goal was to see if it safely reduces acute pain compared to a placebo. Participants took VX-993 tablets or a placebo, and researchers measured pain intensity over 48 hours.

This study compared two similar painkillers—esketamine and ketamine—given as low-dose injections to 74 adults with severe acute pain in the emergency department. The main goal was to see which drug caused fewer disturbing mental side effects like hallucinations or dizziness. Both…

This small pilot study tested whether two NSAIDs (ketorolac and diclofenac) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults received a single dose of one of the three drugs before surgery, and their pain levels were tracked afterw…

This study tested whether a continuous nerve block using the anesthetic ropivacaine can improve recovery after total knee replacement surgery. Sixty patients received either the active nerve block or a placebo. The goal was to see if the continuous block provides better pain reli…

This study tested an experimental drug called LTG-001 for managing pain after a tummy tuck (abdominoplasty). 343 adults took either a high or low dose of LTG-001, a standard painkiller combination, or a placebo. Researchers measured pain relief over 48 hours and tracked how much …

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription took part. The app provided daily tips, tracked pain and side effects, and encouraged p…

This study tested whether a gentle arm massage with sesame-lavender oil can reduce acute pain and anxiety in women after mastectomy surgery. 90 women were randomly assigned to receive massage with either sesame-lavender oil, plain sesame oil, or paraffin oil (a placebo). The goal…

This study looked at whether a simple genetic test can help doctors choose safer and more effective painkillers for women after major gynecologic surgery. About 112 women participated, and half had their pain medicine chosen based on their genes while the other half received stan…

This study tested two different methods to control pain after wrist fracture surgery. One group received a long-lasting numbing medicine (liposomal bupivacaine) plus standard bupivacaine, while the other group received a sedative (dexmedetomidine) plus standard bupivacaine. The g…

This study tested whether a short mindfulness exercise (3 minutes) done in an orthopedic clinic waiting room can help reduce acute pain. Over 600 adults listened to either a mindfulness recording, a pain education recording, or a mix of both. The goal was to see if learning about…

This study tested a realistic breathing toy (a plush dog that moves and sounds like it's breathing) to distract children aged 1-3 during blood draws. Eighty kids were split into two groups: one used the toy, the other got standard care. Results showed the toy group had 51% less p…

This study tested a new drug called MR-107A-02 for treating acute pain after hernia repair surgery. About 579 adults took part, comparing the drug to a placebo and to tramadol, a standard painkiller. The goal was to see if MR-107A-02 reduces pain intensity and the need for extra …

This study tested a new pain medication called PBK_L1704 in 182 people who had foot surgery (bunionectomy) in South Korea. The goal was to see if it relieves moderate to severe pain better than a placebo over 48 hours. Participants received either the drug or a placebo, and pain …

This completed Phase 3 trial tested a new drug called cebranopadol (TRN-228) for moderate to severe acute pain after bunionectomy. 240 participants received either cebranopadol once daily, oxycodone four times daily, or placebo for three days. The study measured pain relief and w…

This study tested a new drug called cebranopadol for treating moderate to severe pain after a tummy tuck (abdominoplasty). 279 adults took either a low or high dose of the drug or a placebo once daily for two days. Researchers measured pain levels over time and how much extra pai…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department with common painful conditions like back pain or abdominal pain. About 290 adults were split into two groups: one received acupuncture, the other got usual care. The goal wa…

This study looked at whether a specific nerve block (external oblique intercostal block) can reduce pain after laparoscopic sleeve gastrectomy, a weight-loss surgery. Twenty patients aged 18-65 participated. Researchers measured how much the block numbed the belly area and how mu…

This study tested a new painkiller called suzetrigine (Journavx) in 47 adults who had laparoscopic or arthroscopic surgery. The goal was to see if it works well and is safe as part of a combination of pain treatments. Participants took the tablet by mouth, and the study is now co…

This study tested the effectiveness and safety of a medicine called suzetrigine, used together with other pain treatments, for acute pain after cosmetic or reconstructive surgery. About 100 adults took part. The goal was to see if patients rated their pain control as good, very g…

This study tested whether a longer-lasting pain medicine (liposomal bupivacaine) given as a nerve block before breast surgery could reduce the need for opioid painkillers after surgery compared to the standard medicine (bupivacaine). 112 adults having partial mastectomy took part…

This completed study tested whether an ultrasound-guided nerve block called RIFP can reduce pain and the need for rescue painkillers after laparoscopic gallbladder removal. 77 patients were enrolled. The block targets nerves in the upper abdomen to provide pain relief. The main g…

This study tested whether an experimental painkiller called XG005 can safely reduce pain after bunion surgery. About 450 adults took either a low dose, high dose, or a placebo pill. Researchers measured pain levels over 48 hours using a simple 0-to-10 pain scale.

This study looked at 1,000 adults with acute low back pain who were at risk of it becoming chronic. Researchers tested whether spinal manipulation therapy combined with guided self-care (like pain education and lifestyle advice) works better than standard medical care. The treatm…

This study tested a new drug called MR-107A-02 for treating acute pain after bunionectomy (foot surgery). 410 adults received either the new drug, a placebo, or tramadol (a standard painkiller). The main goal was to see if MR-107A-02 provides better pain relief than placebo, meas…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study looked at whether a short gratitude exercise can change how people experience pain. 145 healthy adults did a cold water hand test to measure pain. Researchers also checked if certain genes affect the results. The goal was to learn more about how thoughts and biology wo…

This study followed 761 adults who were sent home from the emergency room with a prescription for opioid painkillers for acute pain. Researchers called participants at 1 week, 1 month, and 3 months to ask about pain relief, side effects, and any signs of addiction. The goal is to…

This completed study tracked over 2,200 patients who were prescribed opioids for acute pain after an emergency department visit. Participants recorded how many pills they actually took over two weeks. The goal was to find out the right amount to prescribe, so fewer leftover pills…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This early-stage study tested a new drug called JKN2306 in 44 healthy adults in China. The main goal was to see if single doses are safe and how the body processes the drug, including the effect of food. This trial does not test whether the drug actually relieves pain.

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels afterward. Ten men having hernia repair were randomly assigned to receive either intravenous propofol or inhaled sevoflurane. Researchers measured pain right after surgery and over …

This early-stage study tested a single dose of a new drug called SBS-1000 in 48 healthy adults to see if it is safe and how the body handles it. Participants were randomly assigned to receive either the drug or a placebo by IV. The main goal was to check for side effects and meas…

This study looked at how oxytocin, a natural brain hormone, might reduce pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to create a model of how oxytocin …