ACUTE PAIN

This study looked at whether arm massages with special oils (sesame or sesame-lavender) could reduce acute arm pain and anxiety in women after mastectomy surgery. 90 women were split into three groups: one got massage with sesame oil, one with sesame-lavender oil, and one with pl…

This study tested a mobile app called OPY that helps patients control pain and safely reduce opioid use after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription used the app to track pain, get tips, and receive reminders to stop opioids. The…

This study tested a medicine called suzetrigine for treating acute pain after keyhole surgery (laparoscopy) or joint surgery (arthroscopy). 47 adults took part. The goal was to see how well the medicine worked and if it was safe when used with other pain treatments.

This study tested a new medicine called MR-107A-02 to see if it can safely relieve pain after bunionectomy (foot surgery). About 410 adults took part. The goal was to measure how well the drug reduces pain and whether it can cut down the need for stronger opioid painkillers.

This study tested a new pain medicine called cebranopadol for people with moderate to severe pain after a tummy tuck (abdominoplasty). About 279 adults took part, and some received the drug while others got a placebo. The goal was to see if the drug safely reduces pain over the f…

This study tested an experimental pain medication called MR-107A-02 in 579 adults who had hernia surgery. The goal was to see if it reduces pain better than a placebo or an existing painkiller. Participants rated their pain on a 0-10 scale, and researchers also tracked how much e…

This study looked at whether a special nerve block called RIFP can help control pain after laparoscopic gallbladder removal. 77 adults having this surgery received either the block or standard care. The goal was to see if the block reduces the need for extra painkillers, includin…

This study tested a realistic breathing toy to distract children aged 1-3 during blood draws. Eighty kids were split into two groups: one used the toy, the other received standard care. The toy group had 51% less pain and 72% less crying, with no side effects. It's a simple, safe…

This study tested whether a drug called esketamine causes fewer disturbing side effects than standard ketamine when used for severe pain in the emergency room. 74 adults with severe acute pain received either esketamine or ketamine through an IV. The main goal was to see how many…

This study tested a medicine called suzetrigine for treating short-term pain after cosmetic or reconstructive surgery. About 100 adults took the drug as part of a combination of pain treatments. The goal was to see if it worked well and was safe.

This study tested a new drug called LTG-001 to see if it can safely reduce pain after a tummy tuck (abdominoplasty). About 343 adults took either the drug or a placebo for 48 hours after surgery and reported their pain levels. The goal was to find the best dose and see if it lowe…

This study tested whether a continuous nerve block (a small tube that delivers numbing medicine for longer) helps people recover better after total knee replacement surgery. 60 adults having their knee replaced as an outpatient took part. The goal was to see if this approach impr…

This study tested whether teaching patients about mindfulness before a brief meditation session helps them feel less pain. Over 600 adults in an orthopedic clinic waiting room took part. The goal was to see if a little education makes the meditation work better for acute pain rel…

This study tested an experimental pain medication called XG005 in 450 adults who had bunion surgery. Participants received either a low dose, high dose, or a placebo (sugar pill) and reported their pain levels over 48 hours. The goal was to see if XG005 could safely reduce pain a…

This study looked at 1000 adults with a new flare-up of low back pain who were at risk for long-term disability. Researchers compared spinal manipulation plus guided self-care against standard medical care. The goal was to see if these treatments could reduce pain and disability …

This study tested a new pain medication called cebranopadol in 240 adults who had bunion surgery. The goal was to see if it safely reduces moderate to severe acute pain better than a placebo or an active comparator. Participants were randomly assigned to receive the drug, a place…

This study tested whether common anti-inflammatory drugs (NSAIDs) work as well as a mild opioid for pain after minor surgery. Thirty adults received one of three painkillers before their operation. Researchers measured their pain levels in the recovery room to see which drug prov…

This study tested two different methods to control pain after wrist fracture surgery. One group received a long-lasting painkiller (liposomal bupivacaine) plus standard medication, while the other group received a sedative (dexmedetomidine) plus standard medication. The goal was …

This study tested a nerve block called the external oblique intercostal block to manage pain after laparoscopic sleeve gastrectomy in 20 obese patients. The goal was to see how well it numbs the belly area and reduces the need for strong painkillers in the first day after surgery…

This study tested whether a longer-lasting pain medicine (liposomal bupivacaine) works better than standard bupivacaine for controlling pain after breast surgery. 112 adults having partial mastectomy received one of the two medicines via ultrasound-guided injection. The goal was …

This study looked at whether testing people's genes before surgery can help doctors choose pain medicines that work better and are safer. About 1,600 adults and children having planned surgeries were randomly assigned to get either gene-guided pain treatment or standard care. The…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department. Researchers enrolled 290 adults with acute pain (like back or abdominal pain) and compared acupuncture to usual care. The goal was to see if a larger study is possible and …

This study tested whether an experimental medication called PBK_L1704 works better than a placebo (inactive pill) at reducing pain after bunion surgery. It involved 182 patients in South Korea who had moderate to severe pain following their operation. Researchers measured how muc…

This study looked at how oxytocin, a natural brain hormone, affects pain from heat. 25 healthy adults and people with chronic pain rated their pain during skin heating before, during, and after receiving oxytocin through an IV. The goal was to understand how oxytocin works in the…

This study screened over 4,000 people to see if genetic testing could help doctors choose better medicines for depression, acute pain, or chronic pain. Participants were randomly assigned to get genetic-guided treatment right away or after six months. The goal was to learn whethe…

This early-stage study tested a single dose of a new drug called SBS-1000 in 48 healthy adults to see if it is safe and how the body handles it. Participants were randomly assigned to receive either the drug or a placebo by IV. The main goal was to check for side effects, not to …

This study looked at whether a genetic test can help doctors choose safer and more effective pain medicines for women after gynecologic surgery. About 112 women participated, and half had their painkiller choice guided by the test while the other half received standard care. The …

This study looked at whether the type of anesthesia used during hernia surgery affects pain levels right after surgery and in the long term. Ten men having hernia repair were randomly assigned to receive either total intravenous anesthesia (TIVA) or inhaled anesthesia. Researcher…

This study looked at whether a short gratitude exercise can change how people feel pain. 145 healthy adults took part, and researchers measured their pain during a cold water test. They also checked if certain genes linked to pain and emotions made a difference.

This study followed 761 adults who were sent home from the emergency room with a prescription for opioid painkillers for acute pain. Researchers called patients at 1 week, 1 month, and 3 months to ask how many pills they took, how well their pain was controlled, what side effects…

This study looked at how many opioid pain pills patients actually take after leaving the emergency room with acute pain (like from a fracture). Over 2,200 people from 6 Canadian hospitals recorded their pill use for 14 days. The goal was to help doctors prescribe just the right a…

This early-stage study tested a single dose of a new drug called JKN2306 in 44 healthy adults in China. The main goal was to check if it is safe and how the body processes it, including whether a high-fat meal changes its effects. The study did not treat pain directly but gathere…