ACUTE PAIN

This study tested whether using a person's genetic information could help doctors choose more effective pain medications after surgery. Over 1,600 participants having planned surgeries were randomly assigned to either receive standard care or have their pain medication choices gu…

This study tested if a combination of spinal manipulation (like chiropractic adjustment) and guided self-care coaching could prevent a recent, painful back flare-up from turning into long-term, disabling chronic pain. It involved 1,000 adults at risk for chronic pain and compared…

This early-stage study tested the safety of a new pain medication called SBS-1000 in healthy adults. Researchers gave increasing doses to 48 participants to see how their bodies handled the drug and to check for side effects. The goal was to determine safe dosage levels before te…

This study tested whether an investigational drug called MR-107A-02 works better than a placebo (inactive pill) or standard pain medication for relieving acute pain after bunion removal surgery. It involved 410 patients who had moderate to severe pain after their nerve block wore…

This study tested whether a new pain medication called cebranopadol works better than a placebo (a dummy pill) for people with moderate to severe pain after a tummy tuck surgery. About 279 people who had the surgery were randomly assigned to receive either the real drug or the pl…

This study tested whether a new drug called cebranopadol is safe and effective for reducing moderate to severe pain after bunion surgery. It compared the new drug to a placebo (a dummy pill) and an active pain medication in 240 people who had the surgery. The main goal was to see…

This study tested two different numbing medicines given during breast surgery to see which one better controls pain afterward. Researchers compared a standard numbing medicine to a newer, longer-lasting version. They measured how much opioid pain medication patients needed and tr…

This study tested whether a brief mindfulness session could help reduce pain for patients waiting in an orthopedic clinic. Researchers also wanted to see if explaining how mindfulness works beforehand made it more effective. Over 600 adult patients participated in the trial, whic…

This study tested whether a new oral medication, XG005, could safely reduce pain after bunion surgery. 450 people who had the surgery received either a low dose, a high dose, or a placebo pill for three days while staying in a clinic. Researchers measured their pain levels closel…

This study looked at a specific nerve block technique to help control pain after laparoscopic sleeve gastrectomy, a common weight loss surgery. Researchers tested how well the block numbed the abdominal area and whether it reduced patients' pain scores and need for opioid painkil…

This was the first study in humans for a new oral tablet called JKN2306, intended to treat acute pain. Researchers tested single doses in 44 healthy adults to see if it was safe and how the body processes it. They also checked if eating a high-fat meal changed how the drug worked…

This study tested whether an investigational drug called PBK_L1704 works better than a placebo (inactive pill) at reducing moderate to severe pain after bunion surgery. It involved 182 people in South Korea who had this specific foot operation. Researchers measured how much pain …

This study tested two different methods to control pain after surgery for a broken wrist. Researchers compared a newer, long-lasting numbing medicine against a standard numbing medicine mixed with another drug. The goal was to see which method provided better and longer pain reli…

This study looked at whether the type of anesthesia used during hernia surgery affects how much pain patients feel afterward, both in the short term and long term. Male patients having hernia repair were randomly assigned to receive one of two common anesthesia methods. Researche…

This study tested a new type of nerve block to see if it could better manage pain after laparoscopic gallbladder removal. Researchers gave 77 patients an ultrasound-guided injection of numbing medicine near their ribs before surgery. The goal was to see if this block reduced the …

This study tested how well and how safely the drug suzetrigine worked when used as part of a multi-drug plan to manage pain after cosmetic or reconstructive surgery. It involved 100 adults who were expected to need strong pain medication for at least 3 days after their procedure.…

This study tested if a special toy that looks and sounds like it's breathing could help reduce pain and fear in young children getting a blood test. Eighty children, aged 1 to 3, were randomly given either the breathing toy to hold or received standard care during the procedure. …

This study tested whether an investigational drug called MR-107A-02 could safely and effectively relieve acute pain after hernia repair surgery. It involved 579 adults who had just undergone the operation and were experiencing moderate to severe pain. The drug was compared agains…

This study tested whether a new oral medication called LTG-001 could relieve pain after tummy tuck surgery. Researchers enrolled 343 adults who had the procedure and gave them either the drug or a placebo for 48 hours. They measured how well it reduced pain and whether patients n…

This study tested whether suzetrigine helps control pain after laparoscopic abdominal surgery or arthroscopic joint surgery. Researchers enrolled 47 patients who would normally need opioid pain medication after these procedures. They measured how well the drug worked and checked …

This study tested whether offering acupuncture is a practical way to help manage pain for adults visiting the emergency department. Researchers compared acupuncture to standard pain care across three hospitals to see if it was feasible to run a larger future trial. They measured …

This study aimed to find out exactly how many opioid pain pills patients actually use when recovering from short-term pain at home. Researchers followed over 2,200 patients from emergency departments who were sent home with an opioid prescription. The goal was to gather data to h…

This study aimed to understand how the hormone oxytocin affects pain when given through an IV. Researchers tested 25 healthy volunteers and people with knee arthritis by applying heat to their skin and measuring pain levels before, during, and after receiving oxytocin. The goal w…

This study aimed to understand if a short writing exercise about gratitude could change how people feel and cope with brief, experimental pain. Researchers had 145 healthy adults write about things they were grateful for or about neutral topics, then tested their pain tolerance b…