New pill VX-993 tested for Post-Surgery pain relief

NCT ID NCT06619847

Completed Symptom relief Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested the drug VX-993 in 367 people who had bunion surgery. The goal was to see if it safely reduces acute pain compared to a placebo. Participants took VX-993 tablets or a placebo, and researchers measured pain intensity over 48 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VX-993 (oral tablet)
What this could lead to: If successful, this could provide a new option for managing short-term pain after surgery.
What could go wrong: This is an early-phase trial (Phase 2) with a small sample focused on one surgery type. Results may not apply to other pain types, and the drug may not prove effective or safe enough for approval.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN

Contacts and locations

Locations

Arizona Research Center

Phoenix, Arizona, 85053, United States
Atlanta Center for Medical Research

Atlanta, Georgia, 30331, United States
BioBehavioral Research of Austin

Austin, Texas, 78759, United States
Clinical Pharmacology of Miami

Miami, Florida, 33172, United States
Endeavor Clinical Trials

San Antonio, Texas, 78240, United States
ForCare Clinical Research

Tampa, Florida, 33613, United States
HD Research LLC | First Surgical Hospital

Bellaire, Texas, 77401, United States
HD Research LLC | Legent Orthopedic Hospital

Carrollton, Texas, 75006, United States
JBR Clinical Research

Salt Lake City, Utah, 84107, United States
Memorial Hermann Village

Houston, Texas, 77043, United States
New Hope Research Development | Tarzana, CA

Tarzana, California, 91356, United States
Shoals Medical Trials Inc.

Sheffield, Alabama, 35660, United States
Trovare Clinical Research

Bakersfield, California, 93301, United States
Woodland International Research Group

Little Rock, Arkansas, 72211, United States

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