Could a pill replace a needle for emergency pain relief?

NCT ID NCT01586143

Completed Symptom relief Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether a 125 mg paracetamol tablet that dissolves in the mouth can relieve acute pain as effectively as a 1 g intravenous (IV) infusion. Adults aged 18 to 60 with moderate pain from minor limb injuries in the emergency room will be randomly assigned to one of the two treatments. Pain levels will be tracked using a visual analogue scale at several time points after dosing to compare the two approaches.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paracetamol
What this could lead to: If effective, a mouth-dissolving paracetamol tablet could offer a simpler, less invasive way to manage acute pain in emergency settings, potentially reducing the need for IV lines.
What could go wrong: This is a small Phase 3 trial, and the mouth-dissolving tablet may not work as quickly or as strongly as the IV form. Results may not apply to all types of pain or patients.

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain Sprains and Strains

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN

Contacts and locations

Locations

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

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