New Once-Daily pill could ease Post-Surgery pain

NCT ID NCT06545097

Completed Symptom relief Sponsor: Tris Pharma, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a new drug called cebranopadol for treating moderate to severe pain after a tummy tuck (abdominoplasty). 279 adults took either a low or high dose of the drug or a placebo once daily for two days. Researchers measured pain levels over time and how much extra pain medicine was needed. The goal is to see if this drug offers a safe and effective option for managing acute pain after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cebranopadol (also called TRN-228)
What this could lead to: If successful, this could provide a new once-daily painkiller for people recovering from surgery, reducing the need for rescue medication.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. The drug may not prove significantly better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Acute Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN

Contacts and locations

Locations

ALLEVIATE 1 Site 001106

Little Rock, Arkansas, 72211, United States
ALLEVIATE 1 Site 001110

Bellaire, Texas, 77401, United States
ALLEVIATE 1 Site 001111

San Antonio, Texas, 78240, United States
ALLEVIATE 1 Site 001112

Miami, Florida, 33014, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.