Can common anti-inflammatories replace opioids for post-surgery pain?
NCT ID NCT07500454
First seen Apr 05, 2026 · Last updated Jun 22, 2026 · Updated 16 times
Summary
This small pilot study tested whether two NSAIDs (ketorolac and diclofenac) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults received a single dose of one of the three drugs before surgery, and their pain levels were tracked afterward. The goal is to see if safer, non-opioid options can effectively manage acute postoperative pain.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hospital Regional "General Ignacio Zaragoza," ISSSTE
Mexico City, Mexico City, 09360, Mexico
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tramadol, ketorolac, diclofenac
What this could lead to
If NSAIDs work as well as tramadol, doctors may use them more often for post-surgery pain, reducing reliance on opioids and their side effects.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. It also only tested single doses before surgery, not long-term use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.