Can common anti-inflammatories replace opioids for post-surgery pain?

NCT ID NCT07500454

Completed Symptom relief Sponsor: ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This small pilot study tested whether two NSAIDs (ketorolac and diclofenac) work as well as a weak opioid (tramadol) for pain after minimally invasive surgery. Thirty adults received a single dose of one of the three drugs before surgery, and their pain levels were tracked afterward. The goal is to see if safer, non-opioid options can effectively manage acute postoperative pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tramadol, ketorolac, diclofenac
What this could lead to: If NSAIDs work as well as tramadol, doctors may use them more often for post-surgery pain, reducing reliance on opioids and their side effects.
What could go wrong: This is a small pilot study with only 30 participants, so results may not apply to everyone. It also only tested single doses before surgery, not long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN POSTOPERATIVE PAIN

Contacts and locations

Locations

Hospital Regional "General Ignacio Zaragoza," ISSSTE

Mexico City, Mexico City, 09360, Mexico

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