Nasal spray vs injection: which ketamine route eases trauma pain faster?
NCT ID NCT05229055
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This trial tests whether ketamine given as a nasal spray works as well as ketamine injected under the skin for treating acute pain from limb injuries in the emergency department. About 1,000 adults with moderate to severe pain will be randomly assigned to one of the two methods. The study measures pain reduction after 30 minutes and tracks any serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ketamine
- What this could lead to
- If successful, this could establish a fast, effective, and well-tolerated pain relief option for emergency patients with acute trauma.
- What could go wrong
- This is a mid-stage trial; results may not confirm superiority or non-inferiority of one route over the other. Side effects like sedation or dissociation are possible with ketamine.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
university of Monastir
Monastir, 5000, Tunisia
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