ACUTE PAIN

This study tests an IV medicine called Combogesic IV, which combines ibuprofen and acetaminophen, in children aged 2 to 17 with acute pain. The goal is to see how the body handles the drug and if it is safe. About 60 children will receive the medicine every 6 hours for up to 5 da…

This study compares two simple methods—cold spray and squeezing a stress ball—to standard care for reducing pain during a shot in the muscle. About 66 adults getting a common painkiller injection will take part. Researchers will measure pain, comfort, and satisfaction right after…

This study tests whether a numbing injection (retrolaminar block) given before lumbar spine fusion surgery can lower the amount of strong painkillers (opioids) needed afterward. About 44 adults will be randomly assigned to receive either the real block or a fake one. The main goa…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to see if they can reduce pain, anxiety, and stress during episiotomy repair (stitching) after childbirth. About 120 first-time mothers will be randomly assigned to one…

This study tests two different nasal sprays (sufentanil and ketamine) to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free …

This study compares two ultrasound-guided nerve blocks (RIFPB and TAPB) for pain control after laparoscopic gallbladder removal. 90 adults scheduled for surgery will receive one of the two blocks, and their pain levels and opioid use will be tracked for 24 hours. The goal is to s…

This study tests whether a special nerve block called M-TAPA can reduce pain and the need for strong painkillers after open-heart surgery. About 80 adults having elective open-heart surgery will receive either the nerve block plus standard care or standard care alone. The goal is…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when getting an IV. About 100 adults will be randomly assigned to either use the device or receive standard care. The goal is to find a low-cost, easy way to improve the patient …

This study tests if listening to a short audio-guided mindfulness exercise can help reduce pain for people waiting to see an orthopedic doctor. About 300 adults will be randomly assigned to different lengths of mindfulness practice. The goal is to see if even a brief session can …

This study aims to develop a better way to test how pain medicines work in healthy adults. Up to 25 volunteers will receive two different pain relievers and a placebo, then undergo short, controlled pain tests like cold water and temporary sunburn-like skin sensitivity. The goal …

This study will use a special brain imaging technique (fNIRS) to measure how virtual reality (VR) changes brain activity and reduces pain in children aged 6-17 who have burn injuries. Four children will have their brain signals recorded during burn dressing changes with and witho…

This study involves 14-18 healthy volunteers who will receive three different types of quadratus lumborum blocks on separate days. The goal is to compare how each block affects skin sensation and leg strength. Results will help doctors choose the best approach for managing pain a…

This study tests two different methods of giving a nerve block to numb the front of the belly. 25 healthy adults will receive the block either with the ultrasound probe placed sideways or lengthwise to see which spreads the numbing medicine better. The goal is to improve pain con…