ACUTE PAIN

This study tests a new intravenous medicine called Combogesic IV, which combines two common pain relievers (acetaminophen and ibuprofen) into one infusion. It will involve 60 children aged 2 to 17 with acute pain who need IV pain relief. The goal is to see how the body processes …

This study tests two simple, no-cost methods to reduce pain and fear in children aged 6-12 during blood draws: rhythmic skin tapping by a nurse just above the needle site, and the child humming an 'mmmm' sound. Both techniques are based on the idea that touch and vibration can pa…

This study tests whether adding a long-acting form of bupivacaine to the standard painkiller can prevent the sudden severe pain that often occurs when a nerve block wears off after orthopedic surgery. Researchers will compare the combination against the standard painkiller alone …

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when placing an IV. One hundred adults who need an IV will be randomly assigned to either use the ShotBlocker or receive standard care. The goal is to find a simple, low-cost way…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching) after giving birth. About 120 women will be randomly assigned to one of these…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study tests whether a modified nerve block called M-TAPA, given before open-heart surgery, can reduce pain and the need for strong painkillers (opioids) afterward. The block is injected under ultrasound guidance near the ribs. Eighty adults having elective open-heart surgery…

This study compares two simple methods—cold spray and squeezing a stress ball—to standard care for reducing pain during a shot. 66 adults getting a muscle injection will be randomly assigned to one of three groups. Pain levels will be measured right after the injection to see whi…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This study tests two different ultrasound-guided injection methods for numbing the abdominal wall in 25 healthy adults. One method uses a sideways (transverse) needle approach, the other a lengthwise (longitudinal) approach. Researchers will measure how much skin area becomes num…

This early-phase trial investigates whether m-Cresol, a preservative used in many injectable medications like insulin, causes pain at the injection site. Eighteen healthy volunteers will receive three injections in their belly: one with a low concentration of m-Cresol, one with a…

This study tests three different ways to numb the abdomen in healthy volunteers to see which works best. Each volunteer gets all three blocks on separate days, and researchers map the numb areas and check leg strength. The goal is to improve pain relief after surgery without usin…

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…