Pain-Free shots? study tests if preservative is the culprit

NCT ID NCT07600814

Not yet recruiting Knowledge-focused Sponsor: Medical University of Vienna Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial investigates whether m-Cresol, a preservative used in many injectable medications like insulin, causes pain at the injection site. Eighteen healthy volunteers will receive three injections in their belly: one with a low concentration of m-Cresol, one with a higher concentration, and one without the preservative. They will rate their pain every 5 seconds until it stops. The goal is to see if m-Cresol is a major source of injection pain, which could lead to more comfortable drug formulations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: m-Cresol (a preservative used in injectable medications)
What this could lead to: If this trial shows m-Cresol causes pain, it could lead to reformulating common injectable drugs like insulin to be less painful, improving patient comfort and adherence.
What could go wrong: This is a very early, small study in only 18 healthy volunteers, not patients. The results may not reflect real-world use or lead to immediate changes in drug formulations.

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Conditions

The condition(s) this trial relates to.

Acute Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN HEALTHY VOLUNTEER STUDY PAIN

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Other studies related to the condition(s) this trial covers.