New pain test battery could speed up drug development

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand bath and a temporary sunburn-like skin sensitivity. The goal is to see if this testing approach can tell the difference between medicines that work in the brain versus those that reduce inflammation. This study is not expected to help participants directly but may improve how future pain treatments are tested.