New pain pill could replace opioids after surgery
NCT ID NCT06887959
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new painkiller called suzetrigine (Journavx) in 47 adults who had laparoscopic or arthroscopic surgery. The goal was to see if it works well and is safe as part of a combination of pain treatments. Participants took the tablet by mouth, and the study is now complete.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
suzetrigine (also called VX-548 or Journavx), a pain-relief tablet
What this could lead to
If it works, this could offer a new non-opioid option for managing short-term pain after common surgeries, potentially reducing reliance on opioids.
What could go wrong
This is a small, completed Phase 4 study with only 47 participants. Results are not yet reported, and effectiveness in real-world settings may differ. Pain relief varies by individual.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cooper University HealthCare (CUH)
Camden, New Jersey, 08103, United States
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Duke University Hospital - Anesthesiology
Durham, North Carolina, 27710, United States
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Eximia Research-Durham
Durham, North Carolina, 27704, United States
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Gulfcoast Research Institute
Sarasota, Florida, 34232, United States
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HD Research LLC | First Surgical Hospital
Bellaire, Texas, 77401, United States
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MedStar
Baltimore, Maryland, 21218, United States
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Memorial Hermann Village
Houston, Texas, 77043, United States
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North Shore University Hospital - Anesthesiology
Manhasset, New York, 11030, United States
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Oasis Clinical Research
Las Vegas, Nevada, 89121, United States
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OrthoCarolina - Hip & Knee Center
Charlotte, North Carolina, 28207, United States
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Scottsdale Clinical Trials
Scottsdale, Arizona, 85260, United States
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Seaside Clinical Research Institute
Wilmington, North Carolina, 28412, United States
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Tidewater Clinical Research
Norfolk, Virginia, 23502, United States
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UH Cleveland Medical Center - Anesthesiology
Cleveland, Ohio, 44106, United States
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University of Tennessee Medical Center - Anethesiology
Knoxville, Tennessee, 37920, United States
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West Clinical Research
Morehead City, North Carolina, 28557, United States
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Woodland International Research Group
Little Rock, Arkansas, 72211, United States