New pain pill could replace opioids after surgery

NCT ID NCT06887959

Completed Symptom relief Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new painkiller called suzetrigine (Journavx) in 47 adults who had laparoscopic or arthroscopic surgery. The goal was to see if it works well and is safe as part of a combination of pain treatments. Participants took the tablet by mouth, and the study is now complete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: suzetrigine (also called VX-548 or Journavx), a pain-relief tablet
What this could lead to: If it works, this could offer a new non-opioid option for managing short-term pain after common surgeries, potentially reducing reliance on opioids.
What could go wrong: This is a small, completed Phase 4 study with only 47 participants. Results are not yet reported, and effectiveness in real-world settings may differ. Pain relief varies by individual.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN

Contacts and locations

Locations

Cooper University HealthCare (CUH)

Camden, New Jersey, 08103, United States
Duke University Hospital - Anesthesiology

Durham, North Carolina, 27710, United States
Eximia Research-Durham

Durham, North Carolina, 27704, United States
Gulfcoast Research Institute

Sarasota, Florida, 34232, United States
HD Research LLC | First Surgical Hospital

Bellaire, Texas, 77401, United States
MedStar

Baltimore, Maryland, 21218, United States
Memorial Hermann Village

Houston, Texas, 77043, United States
North Shore University Hospital - Anesthesiology

Manhasset, New York, 11030, United States
Oasis Clinical Research

Las Vegas, Nevada, 89121, United States
OrthoCarolina - Hip & Knee Center

Charlotte, North Carolina, 28207, United States
Scottsdale Clinical Trials

Scottsdale, Arizona, 85260, United States
Seaside Clinical Research Institute

Wilmington, North Carolina, 28412, United States
Tidewater Clinical Research

Norfolk, Virginia, 23502, United States
UH Cleveland Medical Center - Anesthesiology

Cleveland, Ohio, 44106, United States
University of Tennessee Medical Center - Anethesiology

Knoxville, Tennessee, 37920, United States
West Clinical Research

Morehead City, North Carolina, 28557, United States
Woodland International Research Group

Little Rock, Arkansas, 72211, United States

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