DNA test may help doctors pick safer painkillers for surgery patients

NCT ID NCT05966129

Completed Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether genetic testing for two liver enzymes (CYP2D6 and CYP2C19) can help doctors prescribe better pain medicines after surgery. Over 1,600 participants were randomly assigned to either immediate genetic testing and tailored pain treatment or standard care. The goal was to see if the genetic approach reduces pain and opioid use in people whose bodies process certain painkillers slowly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pharmacogenetic testing (genetic test for CYP2D6 and CYP2C19)
What this could lead to: If successful, this could show that genetic testing helps doctors choose safer, more effective pain medicines after surgery, reducing pain and opioid side effects.
What could go wrong: This is a completed pragmatic trial, but results may not apply to all surgeries or populations. The benefit is limited to people with certain genetic variants, and the test itself does not treat pain.

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Conditions

The condition(s) this trial relates to.

Acute Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PAIN

Contacts and locations

Locations

Duke University Medical Center

Durham, North Carolina, 27710, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Meharry Medical College

Nashville, Tennessee, 37208, United States
Nashville General Hospital

Nashville, Tennessee, 37208, United States
Nemours Children's Health System

Wilmington, Delaware, 19803, United States
Nemours Children's Health System

Jacksonville, Florida, 32207, United States
Nemours Children's Health System

Orlando, Florida, 32827, United States
Sanford Health

Fargo, North Dakota, 58104, United States
University of Florida - Gainesville

Gainesville, Florida, 32610, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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