DNA test may help doctors pick safer painkillers for surgery patients
NCT ID NCT05966129
First seen Mar 22, 2026 · Last updated Jun 23, 2026 · Updated 11 times
Summary
This study tested whether genetic testing for two liver enzymes (CYP2D6 and CYP2C19) can help doctors prescribe better pain medicines after surgery. Over 1,600 participants were randomly assigned to either immediate genetic testing and tailored pain treatment or standard care. The goal was to see if the genetic approach reduces pain and opioid use in people whose bodies process certain painkillers slowly.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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Meharry Medical College
Nashville, Tennessee, 37208, United States
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Nashville General Hospital
Nashville, Tennessee, 37208, United States
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Nemours Children's Health System
Wilmington, Delaware, 19803, United States
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Nemours Children's Health System
Jacksonville, Florida, 32207, United States
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Nemours Children's Health System
Orlando, Florida, 32827, United States
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Sanford Health
Fargo, North Dakota, 58104, United States
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University of Florida - Gainesville
Gainesville, Florida, 32610, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pharmacogenetic testing (genetic test for CYP2D6 and CYP2C19)
What this could lead to
If successful, this could show that genetic testing helps doctors choose safer, more effective pain medicines after surgery, reducing pain and opioid side effects.
What could go wrong
This is a completed pragmatic trial, but results may not apply to all surgeries or populations. The benefit is limited to people with certain genetic variants, and the test itself does not treat pain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.