POST OPERATIVE PAIN

This study tests two nano-sized medications placed inside the tooth to control infection and inflammation after a root canal has failed. About 63 adults with a persistent tooth infection will receive either nano-calcium hydroxide or nano-chitosan. The goal is to see which better …

This study looks at a procedure that freezes certain nerves in the chest to reduce pain after heart or lung surgery. It involves up to 5,000 people aged 12 and older who either get the freezing treatment or standard care. Researchers will track pain levels and any side effects fo…

This study compares pain control using only non-opioid drugs (acetaminophen and ibuprofen) versus including an opioid (oxycodone) after laparoscopic tubal sterilization. About 38 women undergoing the procedure will report their pain scores and satisfaction. The goal is to see if …

This study tests whether a pre-surgery program of exercise and a dietary supplement called Ocoxin can improve recovery for 100 women undergoing surgery for gynecologic cancers like endometrial, ovarian, or cervical cancer. Participants will follow an enhanced recovery protocol (E…

This study compares two pain relief methods after cesarean section: a nerve block (ESPB) and spinal morphine. It involves 52 women having planned C-sections. The goal is to see which method leads to better recovery and less pain. Results could help improve post-surgery care for m…

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the need for other opioid painkillers right after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and …

This study compares two numbing medicines injected during scoliosis surgery to see which one better controls pain and reduces the need for strong opioid painkillers. About 128 teens aged 10 to 17 will be randomly assigned to receive either a long-acting numbing drug (liposomal bu…

This study compares two methods of numbing the shoulder after total shoulder replacement: a continuous catheter that delivers pain medicine over time versus a single injection of long-lasting medication. About 56 adults having shoulder replacement will be randomly assigned to one…

This study tests whether adding suzetrigine, a new non-opioid pain drug, to standard pain management can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults will be randomly assigned to receive either suzetrigine or a placebo alongside usual ca…

This study compares two ultrasound-guided nerve blocks—supra-inguinal fascia iliaca block and pericapsular nerve group block—to see which one better reduces pain when positioning patients for spinal anesthesia during femur fracture surgery. Seventy adults with a broken femur will…

This study tests whether a common cough medicine, dextromethorphan, can reduce pain and the need for strong painkillers after knee replacement surgery. About 160 adults will receive either dextromethorphan or a placebo before and after their operation. Researchers will measure ho…

This study tests whether a special nerve block called M-TAPA can reduce pain after laparoscopic abdominal surgery in children. Sixty kids aged 1 to 7 will be randomly assigned to get either the M-TAPA block or standard local anesthetic at the surgical cuts. The main goal is to se…

This study tests whether giving a single dose of methadone during hip replacement surgery can lower pain and reduce the need for other opioids afterward. Researchers will compare pain scores and opioid use in 162 adults who receive either methadone or a placebo during surgery. Th…

This study compares two ultrasound-guided nerve blocks—serratus intercostal plane block and erector spinae plane block—for pain control after open kidney removal. 132 adults scheduled for elective open nephrectomy will be randomly assigned to receive one of the two blocks. The go…

This study compares two types of nerve blocks—suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB)—for pain relief after hip fracture surgery. Researchers will enroll 70 adults undergoing hip fracture repair and measure pain scores and opioid use. The goal…

This study looks at whether a continuous pain pump delivering bupivacaine (a numbing medicine) after a C-section reduces the need for stronger opioid painkillers compared to a placebo pump with salt water. One hundred pregnant women having C-sections will be randomly assigned to …

This study tests whether a nerve block (injecting numbing medicine near a nerve in the ear) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having ear surgery will be randomly assigned to get the nerve block or standard care. The main…

This study compares two methods for controlling pain after same-day orthopedic surgeries like ACL repair or rotator cuff surgery. One group gets a continuous pain pump that delivers numbing medicine for days, while the other gets a single injection nerve block before surgery. Res…

This study compares two ways of giving morphine after a planned C-section: through a shot in the spine (intrathecal) or through a small tube near the spine (epidural). The goal is to find which method provides better pain relief with fewer side effects like nausea or itching. Abo…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement surgery can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or sur…

This study compares two types of root canal sealers—resin-based and bioceramic—to see which causes less pain after treatment. About 180 adults with infected single-root teeth will be randomly assigned to one sealer. Pain levels are measured 24 and 48 hours later using a simple 0-…

This study tests three treatments for teeth with deep cavities and severe, constant pain: total pulpotomy, radicular pulpotomy, and standard root canal. About 99 adults will receive one of these procedures, and their pain and healing will be tracked for a year. The goal is to fin…

This study tests if giving acetazolamide (Diamox) before laparoscopic hysterectomy can lessen pain after surgery, especially pain from the gas used in the abdomen. About 100 women having the surgery will receive either the drug or a placebo. Their pain levels and painkiller use w…

This study compares two common medications, dexmedetomidine and dexamethasone, when added to a nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 will take p…

This study tests whether giving methadone during and after major spine surgery can reduce the need for other opioids three months later. About 120 adults having multi-level spine fusion will be randomly assigned to receive methadone or a placebo. The goal is to see if this approa…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests whether taking the steroid prednisone after ureteroscopy (a surgery for kidney stones) can help reduce pain and the need for other pain medications. Researchers will enroll 90 adults who are having this surgery with a stent placed. The goal is to see if adding a …

This study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be treated and asked to rate their pain. The goal is to find a better way to man…

This study tests whether a new pain medication called Suzetrigine can help people who have knee replacement surgery feel less pain and need fewer opioids. About 235 adults will be randomly assigned to get either Suzetrigine or a placebo before surgery. The goal is to see if the d…

This study tests whether a presacral nerve block can reduce pain after total laparoscopic hysterectomy. Sixty women will be randomly assigned to receive either the nerve block with a numbing medicine or a placebo (salt water). The main goal is to measure pain levels 3 hours after…

This study looks at whether injecting a long-lasting anesthetic called EXPAREL into the surgical wound can improve pain control and swallowing function in people with oropharyngeal cancer undergoing robotic throat surgery. About 80 adults will take part, and half will receive the…

This study tests whether taking two common pain relievers (acetaminophen and NSAIDs) at different times works better than taking them together after a cesarean delivery. About 825 women who have a C-section will be randomly assigned to one of the two schedules. The goal is to fin…

This study tests a small steroid insert placed in the tear duct to control pain and swelling after vitreoretinal eye surgery. About 30 adults having surgery for a macular hole, epiretinal membrane, or vitreomacular traction will either get the insert or standard steroid eye drops…

This study looks at the forces applied to the tongue and throat during laryngeal surgery. Researchers will measure these forces in 100 adults and see if they relate to pain, numbness, or tongue movement after surgery. In the second half of the study, surgeons will see real-time f…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or when chronic pain flares up. A smaller group will also …

This study aims to understand why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will analyze blood and skin samples from 40 participants to look for unique immune and genetic markers linked to pain. The goal is to find bett…

This study is a large international registry that collects information from patients after surgery to understand how well their pain is managed. Researchers will look at patient-reported outcomes like worst pain, side effects, and satisfaction with treatment. The goal is to impro…

This study looks at how red light and blue light affect tooth temperature during dental work and whether that leads to pain afterward. Researchers will measure temperature changes in the tooth and check in with 50 participants after their procedure. The goal is to see if red ligh…