POST OPERATIVE PAIN

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study tested a new drug called MR-107A-02 for treating acute pain after bunionectomy (foot surgery). 410 adults received either the new drug, a placebo, or tramadol (a standard painkiller). The main goal was to see if MR-107A-02 provides better pain relief than placebo, meas…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This study tested a single injection of F14, a long-acting form of the painkiller celecoxib, given directly into the knee joint during total knee replacement surgery. The goal was to see if it provides better pain relief than standard pain medicines alone. The trial involved 151 …

This study compared two ultrasound-guided nerve blocks—transversalis fascia plane block and erector spinae plane block—for pain relief after inguinal hernia repair. Forty-three men undergoing open hernia surgery received one of the two blocks before the procedure. The goal was to…

This Phase 3 trial tested an experimental long-acting local anesthetic called CPL-01 in 616 people having bunion surgery. The goal was to see if it reduces pain and the need for opioid rescue medication compared to a standard anesthetic or placebo. Participants received the injec…

This study tested whether adding dexamethasone or magnesium sulfate to a standard numbing drug (bupivacaine) could provide longer pain relief after total hip replacement. 66 adults received an ultrasound-guided nerve block before surgery. The main goal was to see how long it took…

This study tested whether adding magnesium to a standard numbing medicine (bupivacaine) improves pain control after total knee replacement. 94 adults received either the combination or bupivacaine alone in a nerve block. The goal was to see if the mixture reduces pain scores and …

This study tested a new medicine called MR-107A-02 to see how well it relieves pain after hernia repair surgery. About 579 adults took part, comparing the new drug to a placebo (fake pill) and an active painkiller. The goal was to measure pain intensity and the need for extra opi…

This study tested two types of nerve blocks to control pain after collarbone surgery. Fifty adults received either a standard block near the neck or a newer block near the collarbone. The goal was to see which provides longer pain relief and causes fewer breathing problems.

This study tested whether giving ketamine during surgery and methadone after surgery can prevent the extra pain sensitivity that opioids sometimes cause. 113 adults having open colorectal surgery took part. The goal was to see if these drugs reduce the area of increased pain arou…

This study looked at whether a simple genetic test can help doctors choose safer and more effective painkillers for women after major gynecologic surgery. About 112 women participated, and half had their pain medicine chosen based on their genes while the other half received stan…

This completed early-phase trial tested three oral painkillers—Novafen, Tramadol, and Naproxen—against a placebo (multivitamins) for pain after root canal treatment. 100 adults with tooth pain took one of the four options, and their pain was measured on a 0–10 scale. The goal was…

This study compared two ways to manage pain after modified radical mastectomy: an ultrasound-guided nerve block (erector spinae plane block) versus injecting anesthetic into the surgical wound. Thirty-seven women participated, and researchers measured how much morphine they neede…

This study tested two types of cold therapy (cryotherapy) to see if they could reduce pain and inflammation after root canal treatment for infected lower premolars. Thirty adults with painful tooth infections were randomly assigned to receive either an ice pack on the cheek, a co…

This study tested an experimental drug called CPL-01 to see if it can control pain after open inguinal hernia surgery. About 518 adults who needed hernia repair received either CPL-01, a placebo, or an active painkiller. Researchers measured pain levels during activity to see how…

This study tested whether multi-port epidural catheters provide better pain relief than single-port catheters after chest or upper abdomen surgery. 240 adults took part. The main goal was to see if multi-port catheters reduce the need for extra pain medicine or catheter replaceme…

This study compared two pain relief methods after bladder removal surgery: a thoracic epidural and a newer ultrasound-guided nerve block. Twenty adults aged 40-70 having planned surgery took part. The goal was to see which method provided longer pain relief and better pain scores…

This study tested whether adding a nerve-freezing procedure during knee replacement surgery could reduce pain and improve function afterward. 70 adults with severe knee arthritis were randomly assigned to get either standard knee replacement or knee replacement plus the nerve abl…

This study looked at whether the 4-7-8 breathing technique can help reduce pain, nausea, and vomiting in people who just had bariatric (weight-loss) surgery. Sixty adults were split into two groups: one practiced the breathing exercise every hour, and the other received standard …

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This study tested whether adding a steroid (dexamethasone) to a standard nerve block could provide longer pain relief after knee replacement surgery. 66 adults scheduled for knee replacement received the nerve block with or without the steroid. The main goal was to see if the ste…

This study tested two types of nerve blocks (erector spinae plane block and serratus anterior plane block) to see which provides better pain relief after breast reduction surgery. 80 women received one of the two blocks, and researchers measured how much pain medication they need…

This study tested whether a non-opioid pain drug called suzetrigine can control pain after outpatient facial plastic surgery and reduce the need for opioid pills. 100 adults took part at Mayo Clinic. Researchers measured how many opioid pills were used in the first week and how m…

This study tested three different pain-relief methods in 102 adults having keyhole lung surgery. The goal was to see which method keeps patients comfortable the longest after the operation. Researchers measured how soon patients needed extra pain medicine and how strong their pai…

This study looked at whether a quadratus lumborum (QL) nerve block can lower pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. Seventy women were randomly assigned to receive either standard enhanced recovery care or a QL block. Researchers…

This study tested two different nerve blocks to see which one works better for pain after laparoscopic inguinal hernia surgery. 90 adults received either a modified thoracoabdominal nerve block (M-TAPA) or a standard transversus abdominis plane (TAP) block. Researchers measured p…

This study looked at 240 adults who had heart surgery to see if giving pain medicine in small, timed doses (boluses) works better than a steady drip (continuous infusion) through a catheter near the spine. The goal was to reduce pain and the need for opioids after surgery. Result…

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study looked at three ways to manage pain during and after hip fracture surgery in 105 patients over 60. One group got a single spinal injection, another got a continuous spinal injection through a tiny tube, and the third got general anesthesia. The goal was to see which me…

This study looked at 63 adults who had heart surgery through a small cut in the chest. It compared two ways to manage pain after surgery: freezing the nerves (cryoanalgesia) versus a nerve block (BRILMA block). The goal was to see which method provides better pain relief and redu…